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Neuroprotective Activity of Curcumin in Animal Models
A systematic review found that curcumin showed neuroprotective activity in preclinical models of Alzheimer's, Parkinson's, multiple sclerosis, and amyotrophic lateral sclerosis. However, over 80% of positive findings from animal studies have not been replicated in humans.
What this does not proveThe findings are limited by incomplete formulation characterization, lack of CNS-exposure biomarkers in trials, and significant discrepancies between animal and human studies.