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In a study of 64 participants, researchers found that VEP-based P100 latency was significantly associated with lower whole brain volume and gray matter volume, as well as greater T2-FLAIR lesion volumes. Specifically, longer P100 latencies correlated with these decreased volumes, suggesting a link between visual evoked potentials and brain structure outcomes in the context of multiple sclerosis.
What this does not proveIt remains unclear whether shifts in VEP latency indicate changes in the visual pathway or are consequences of brain structural changes, limiting the ability to infer causation from these associations.