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Research summary · AI summary · not yet reviewedHuman studyObservationalPeer review unconfirmed
Effects of B Cell Depletion Therapy on EBV-specific T-cells in Multiple Sclerosis
In an observational study of 183 participants, including 54 with MS receiving B cell depletion therapy (BCDT), results showed that BCDT is associated with lower frequencies of EBV-specific T-cells while maintaining T-cell functionality. Notably, patients treated with ofatumumab had higher EBV-specific CD8⁺ T-cell frequencies compared to those treated with ocrelizumab.
What this does not proveThe specific effects of BCDT on EBV-specific immunity are not fully understood, especially compared to untreated MS patients and healthy controls.