Eccentric Cycling Training in People with Multiple Sclerosis

study phaseThese symptoms are transient, and symptomatic treatments (analgesics, stretching, ice) are not permitted.\n\nMultiple variables will be assessed before, during, and after the intervention period to quantify potential effects of each training protocol and allow direct comparison.\n\nDescription of Study Phases\n\nThe study consists of 5 phases over a 12-week period for ambulatory participants and a 4-week period for in-hospitalisation participants (see appendix):\n\nPhase 0: Baseline Testing\n\nOut participants : Measurements will be collected 5-7 days before and 7-14 days after the training period to monitor longitudinal changes and evaluate the impact of the protocols on body composition and functional capacity.\n\nIn participants : Measurements will be collected the fisrt and lest (4th) week of the training program.\n\nEccentric Ergocycle Training Protocol Phase 1: Familiarization (4 weeks)\n\nOut participants:\n\nTwo sessions per week for four weeks.\n\nIn participants:\n\nThree sessions per week for two weeks.

study designParticipation of pregnant women is permitted.\n\nType of Study\n\nThis is a prospective interventional study conducted longitudinally, with all subjects evaluated over the same time period (2025-2027).

subjectsThe study will take place at the Sart-Tilman sites (Blanc-Gravier, Exercise Physiology Unit) or at the CNRF in Fraiture-en-Condroz, depending on participant preference.\n\nNeurological Pathologies Inclusion criteria\n\nParticipants must:\n\npresent with one of the following neurological disorders: Parkinson's disease or multiple sclerosis.\n\nI.

randomizedSubjects will be randomly allocated (stratified by sex and disease stage) into one of the two experimental groups.

controlled"interventionModelDescription": "Participants will be split in 2 groups :\n\none following an eccentric cycling training one following a concentric cycling training",

regulatory approvalThese symptoms are transient, and symptomatic treatments (analgesics, stretching, ice) are not permitted.\n\nMultiple variables will be assessed before, during, and after the intervention period to quantify potential effects of each training protocol and allow direct comparison.\n\nDescription of Study Phases\n\nThe study consists of 5 phases over a 12-week period for ambulatory participants and a 4-week period for in-hospitalisation participants (see appendix):\n\nPhase 0: Baseline Testing\n\nOut participants : Measurements will be collected 5-7 days before and 7-14 days after the training period to monitor longitudinal changes and evaluate the impact of the protocols on body composition and functional capacity.\n\nIn participants : Measurements will be collected the fisrt and lest (4th) week of the training program.\n\nEccentric Ergocycle Training Protocol Phase 1: Familiarization (4 weeks)\n\nOut participants:\n\nTwo sessions per week for four weeks.\n\nIn participants:\n\nThree sessions per week for two weeks.

regulatory approval details"isFdaRegulatedDevice": false

research categoriesThe project aims to optimise functional rehabilitation programmes for people with multiple sclerosis.

relevant ms typesThe study will take place at the Sart-Tilman sites (Blanc-Gravier, Exercise Physiology Unit) or at the CNRF in Fraiture-en-Condroz, depending on participant preference.\n\nNeurological Pathologies Inclusion criteria\n\nParticipants must:\n\npresent with one of the following neurological disorders: Parkinson's disease or multiple sclerosis.\n\nI.

primary endpointMaximal Isometric Force (in Newton-meters - Nm) of the quadriceps will be measured using a fixed dynamometer (Kinvent), at 90 degrees of knee flexion.

findings"briefSummary": "The project aims to optimise functional rehabilitation programmes for people with multiple sclerosis.\n\nInvestigators are proposing eccentric cycling as a new exercise modality for treating these patients.\n\nBased on previous results in healthy subjects, investigators will attempt to define the optimal parameters of this new modality (in terms of duration, intensity, frequency, etc.).\n\nInvestigators also aim to demonstrate the effectiveness of this training (compared to conventional training) in improving muscle function, functional capacity, perception of chronic fatigue, quality of life, physical condition, and neurological and cognitive function.",

limitationsTrial registry record. Publication date: unknown. No results are posted. Planned enrolment and endpoints are not findings.