Immune Biomarkers and Functional Performance in Multiple Sclerosis Patients
This observational study with 20 MS patients evaluated the relationship between peripheral immune biomarkers and their functional performance, specifically using the Multiple Sclerosis Functional Composite (MSFC) measurements. The biomarkers measured included tumor necrosis factor-alpha, interleukin-8, and adiponectin, without any therapeutic interventions introduced.
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Why it matters
Understanding the association between immune biomarkers and functional performance can help inform future research and potentially lead to insights on monitoring or therapeutic strategies for MS.
What this does not prove
The study is purely observational, relying on correlational data without therapeutic interventions or controls; results are pending due to an unknown publication date.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 20 · basis not reported
- Randomised
- No
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Trial registry record
- Regulatory approval
- No
- Research areas
- Not classified
Original sources
Supporting passages (10)
study phaseThe secondary objective is to examine the associations between individual immune biomarkers and the individual components of the MSFC, as well as disability status assessed by the EDSS.\n\nThe study uses an observational correlational design.
study design"detailedDescription": "This is an observational, cross-sectional study investigating the relationship between peripheral immune biomarkers and functional performance in patients with multiple sclerosis (MS).
subjectsThe study is designed to determine whether selected peripheral immune biomarkers are associated with functional performance and disability-related measures in individuals with MS.\n\nParticipants with a diagnosis of multiple sclerosis will be evaluated using clinical, demographic, functional, and laboratory measurements.
sample sizeThe study includes 20 patients with multiple sclerosis.
randomizedThe study does not involve assignment to an intervention group, administration of an investigational treatment, or modification of participants' usual clinical care."
regulatory approvalThe study does not involve assignment to an intervention group, administration of an investigational treatment, or modification of participants' usual clinical care."
intervention"description": "Peripheral immune biomarkers, including tumor necrosis factor-alpha, interleukin-8 (IL-8/CXCL8), and adiponectin, were measured in serum samples collected at baseline.
primary endpointThese characteristics will be considered when describing the study population and evaluating the relationship between immune biomarkers and functional performance.\n\nThe primary objective of the study is to investigate the association between peripheral immune biomarker levels and functional performance in patients with multiple sclerosis.
findingsThese characteristics will be considered when describing the study population and evaluating the relationship between immune biomarkers and functional performance.\n\nThe primary objective of the study is to investigate the association between peripheral immune biomarker levels and functional performance in patients with multiple sclerosis.
limitationsAll assessments were performed using baseline data, and no therapeutic or exercise intervention was administered as part of this study.\n\nPeripheral immune biomarkers evaluated in the study include tumor necrosis factor-alpha (TNF-α), interleukin-8 (IL-8/CXCL8), and adiponectin.
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