Role of PI3K/AKT/mTOR Pathway in Neuroinflammation and Neuroprotection
A systematic review explored the dual role of the PI3K/AKT/mTOR signaling pathway in multiple sclerosis (MS), highlighting its involvement in both promoting inflammation and aiding cell survival in oligodendrocytes. The review found that while activation drives pro-inflammatory responses in certain immune cells, it is also essential for the health of myelinating cells.
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding this pathway helps clarify the complex interactions between inflammation and repair in MS, indicating that any therapeutic targeting must balance these opposing effects to avoid disrupting repair processes.
What this does not prove
The review does not provide direct evidence from clinical trials or specific patient populations, limiting its conclusions.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-17
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Neuroinflammation, Neuroprotection
Original sources
- Primary evidenceThe dual role of the PI3K/AKT/mTOR axis in glial cell survival and neuroinflammation. ↗DOI: 10.1007/s00210-026-05986-3
Supporting passages (6)
study designThe dual role of the PI3K/AKT/mTOR axis in glial cell survival and neuroinflammation.
research categoriesThe PI3K/AKT/mTOR signaling pathway is a master regulator of these divergent cellular processes and therefore represents a biological paradox in multiple sclerosis.
findingsIn the pathogenic facet of the disease, activation of this axis supports the differentiation and effector functions of pro-inflammatory T- and B-cells and contributes to inflammatory programs in microglia and macrophages.
findingsIn the regenerative facet, physiological PI3K/AKT/mTOR activity is required for oligodendrocyte precursor-cell survival, differentiation, myelin synthesis, and maintenance of myelin integrity.
limitationsThis review therefore considers PI3K/AKT/mTOR axis according to these opposing pathogenic and protective functions, highlighting the importance of cell type, disease stage, and treatment timing.
publication datePublication date: 2026-10-17
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