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Research summary · 4 h ago

AI summary · not yet reviewedSubjects not reportedNot reportedPublished in a peer-reviewed journal

Microbiome Composition in Youth with Pediatric Onset Multiple Sclerosis

Youth with pediatric onset multiple sclerosis (POMS) who are inactive had lower levels of Firmicutes and higher levels of Bacteroidetes compared to those who are active. Inactive POMS also showed higher abundance of specific bacteria such as Bifidobacterium and Escherichia-Shigella.

Tags: #MSResearch
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Source: Read original source (PMID 42966336)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Human efficacy: Not established from this source
Mechanism: Not reported
Evidence strength: Not graded
Outcome: Not reported

Why it matters

These findings suggest a potential link between physical activity levels and gut microbiome diversity in youth with POMS, which may have implications for understanding disease mechanisms or management strategies.

What this does not prove

The specific microbiome patterns observed require validation in larger studies that also account for physical activity and other confounding factors.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Not reported
Participants / samples: 113 · Thirty-seven youth with POMS, 40 mono-ADS, and 36 UC
Randomised: No
Controlled: Not reported
Primary endpoint met: Not reported
Relevant MS type: Not reported
Publication date: 2026-10-26
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Not classified
Biological target: Not reported
Pathway: Not reported
Population: youth with pediatric onset multiple sclerosis (POMS), monophasic demyelinating syndromes (mono-ADS), and unaffected controls (UC)
Size of effect: Not reported
Secondary endpoints: Not reported
MRI endpoints: Not reported
Biomarkers: Not reported
Safety: Not reported

Original sources

Primary evidenceGut microbiome and physical activity in paediatric-onset multiple sclerosis. ↗DOI: 10.1016/j.msard.2026.108023

Supporting passages (9)

sample sizeThirty-seven youth with POMS, 40 mono-ADS, and 36 UC

sample size basisThirty-seven youth with POMS, 40 mono-ADS, and 36 UC

randomizedNo

publication date2026-10-26

comparatorOBJECTIVES: To examine associations between physical activity (PA) and gut microbiome diversity and composition in youth with pediatric onset multiple sclerosis (POMS) versus monophasic demyelinating syndromes (mono-ADS) and unaffected controls (UC), and to compare active versus inactive POMS.

findingsInactive POMS had lower Firmicutes and higher Bacteroidetes, with enrichment of Bifidobacterium, Escherichia-Shigella, and Lactobacillus, whereas active POMS showed higher Firmicutes (e.g., Roseburia, Lachnospiraceae); Bifidobacterium was ∼4-fold higher in inactive POMS.

limitationsThese findings should be confirmed in larger cohorts with objective measures of physical activity and more comprehensive assessment of potential confounding factors.

populationOBJECTIVES: To examine associations between physical activity (PA) and gut microbiome diversity and composition in youth with pediatric onset multiple sclerosis (POMS) versus monophasic demyelinating syndromes (mono-ADS) and unaffected controls (UC), and to compare active versus inactive POMS.

peer reviewedPublication types: Journal Article

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