Naringenin in a Cuprizone-Induced Mouse Model
In a controlled study, naringenin improved motor performance in mice with induced demyelination. It led to increased myelin basic protein expression and reduced levels of various inflammatory markers. The treatment also shifted apoptotic signaling towards survival by altering specific protein expressions.
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- #MSResearch
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Why it matters
These findings suggest potential mechanisms by which naringenin may protect against neurodegeneration associated with multiple sclerosis, though established efficacy in humans is not yet determined.
What this does not prove
The study does not establish efficacy in human subjects; results are based on an animal model of demyelination.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Yes
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-01
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceNaringenin confers neuroprotection in a cuprizone-induced mouse model of multiple sclerosis with upregulation of PPAR-γ expression. ↗DOI: 10.1093/jpp/rgag113
Supporting passages (6)
controlledMice were allocated to four groups: control, naringenin alone, cuprizone, and cuprizone plus naringenin.
peer reviewedJournal: The Journal of pharmacy and pharmacology
primary endpointMotor performance and biochemical, molecular, and histological changes were evaluated using established behavioural, immunological, molecular, and histological techniques.
findingsKEY FINDINGS: Naringenin improved motor deficits, increased myelin basic protein expression, reduced tumour necrosis factor-alpha, interleukin-1 beta, cyclooxygenase-2, prostaglandin E2, and nuclear factor kappa B p65 levels, and shifted apoptotic signalling towards cell survival by decreasing Bcl-2-associated X and increasing B-cell lymphoma 2 expression.
publication datePublication date: 2026-09-01
limitationsTitle: Naringenin confers neuroprotection in a cuprizone-induced mouse model of multiple sclerosis with upregulation of PPAR-γ expression.
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