Unknown human subjects in optic neuritis research
In a study involving 51 patients, higher levels of serum neurofilament light chain at baseline were associated with greater differences between eyes in retinal nerve fiber layer thickness and ganglion cell/inner plexiform layer, as well as lower performance in low-contrast letter acuity testing after 24 months.
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Why it matters
These findings suggest that serum neurofilament light chain could serve as a biomarker for assessing neuronal damage in optic neuritis, indicating the potential for monitoring disease progression or recovery.
What this does not prove
The study's design does not allow for conclusions about causation between neurofilament light chain levels and visual or structural outcomes in optic neuritis.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- 51 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-28
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceSerum NfL predicts visual recovery and neuronal loss after optic neuritis. ↗DOI: 10.1177/13524585261489992
Supporting passages (5)
sample sizeFifty-one patients (mean age = 33 years, 71% women) were followed for 24 ± 6 months with low-contrast letter acuity testing and optical coherence tomography.
publication datePublication date: 2026-09-28
follow upFifty-one patients (mean age = 33 years, 71% women) were followed for 24 ± 6 months with low-contrast letter acuity testing and optical coherence tomography.
findingsAdjusting for age and sex, higher baseline serum neurofilament light chain predicted greater inter-eye differences in retinal nerve fibre layer (-4.65 µm per SD, p = 0.02), ganglion cell/inner plexiform layer (-1.39 µm, p = 0.02) and 2.5% low-contrast letter acuity (-0.73, p = 0.05), but not high-contrast acuity.
limitationsTitle: Serum NfL predicts visual recovery and neuronal loss after optic neuritis.
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