Association of Wearing-off Symptoms with Fatigue in NTZ-Treated Participants
In a study with 34 NTZ-treated participants, wearing-off symptoms (WoS) were reported in 67.9% of participants, showing a link with fatigue but no association with dosing intervals, diffusion changes, or serum biomarkers. Wearable data indicated a modest decrease in afternoon steps that corresponded with fatigue scores and WoS rates.
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- #MSResearch
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Why it matters
This research suggests that WoS may be linked to fatigue rather than direct inflammatory or neurodegenerative activity, potentially providing insights into patient experiences.
What this does not prove
The study does not establish a direct cause-and-effect relationship between WoS and disease activity, only an association with fatigue-related changes.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- 34 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-18
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceDigital signatures of fatigue and wearing-off symptoms in patients with multiple sclerosis under natalizumab. ↗DOI: 10.1016/j.neurot.2026.e01075
Supporting passages (5)
sample sizeThirty-four NTZ-treated participants were enrolled; 28 completed 6-month follow-up and 21 provided analyzable smartwatch data.
primary endpointwe investigated whether WoS were associated with inflammatory or neurodegenerative damage and whether wearable monitoring captures related motor changes.
findingsWoS occurred in 19/28 analyzed participants (67.9%) and 63/177 of observed questionnaires (35.6%). WoS rate was associated with fatigue, but not with dosing interval, diffusion changes, or serum biomarkers.
limitationsThese exploratory findings indicate that, in this clinically stable cohort, WoS under NTZ do not reflect ongoing inflammatory or neurodegenerative disease activity, but rather align with fatigue-related motor changes detectable by high-adherence passive wearables.
publication datePublication date: 2026-09-18
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.