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Research summary · AI summary · not yet reviewedHuman studyObservationalPeer review unconfirmed
Human Study on MS Types Using LEAP Profiling
In a study of 56 individuals (28 controls, 14 with RRMS, 14 with SPMS), SPMS was associated with a higher mean ADC near ventricles, higher maximum profile ADC, and a steeper early profile slope compared to controls. RRMS displayed intermediate values between SPMS and controls.
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This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
Why it matters
These findings suggest distinct imaging biomarkers that could differentiate SPMS from RRMS, potentially aiding in understanding disease progression.
What this does not prove
The study had limitations in directly comparing RRMS and SPMS metrics, which may affect the reliability of phenotype distinctions.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 56 · Total number of participants (28 controls, 14 RRMS, 14 SPMS)
- Randomised
- Not reported
- Controlled
- Yes
- Primary endpoint met
- Not reported
- Relevant MS type
- RRMS, SPMS
- Publication date
- 2026-09-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceBoundary-anchored thalamic ADC profiling shows spatially structured abnormalities in multiple sclerosis. ↗DOI: 10.1055/a-2941-6690
Supporting passages (13)
study phaseMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
study designMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
subjectsMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
speciesMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
sample sizeRESULTS: The clearest signal was observed in comparisons between MS and matched controls, with the largest number of differences seen for SPMS versus controls.
sample size basisMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
controlledMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
relevant ms typesMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
publication datePublication date: 2026-09-21
interventionLEAP was applied bilaterally at the medial thalamic surface adjacent to the third ventricle.
comparatorMATERIALS AND METHODS: In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol.
findingsCompared with controls, SPMS showed a higher ventricle-near mean ADC (p = 0.004), higher profile maximum ADC (p = 0.003), and a steeper early profile slope (p = 0.005).
limitationsDirect RRMS-versus-SPMS comparisons of bilateral summary metrics were limited.
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