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Investigating Word-Finding Difficulties in Mice with Multiple Sclerosis
This study found that individuals with multiple sclerosis (MS) reported significantly more word-finding difficulties in connected speech compared to non-brain-damaged controls. Specifically, there were notable differences in types of word-finding difficulties, pauses, and speech rate among the groups.
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This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
These findings highlight the challenges faced by people with MS in their speech production, which could inform future communication strategies and support.
What this does not prove
The study does not establish causation and is limited by a small sample size and reliance on self-reported difficulties.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-06
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceFinding the right words in connected speech: An examination of word-finding difficulties in persons with multiple sclerosis. ↗DOI: 10.1016/j.jcomdis.2026.106699
Supporting passages (6)
sample size basisTwenty-seven PwMS with self-reported anomia and 23 NBD controls performed a video-retelling task which was evaluated by (i) counting the number and types of indicators of word-finding difficulties, (ii) main-concept analysis (MCA), and (iii) correct-information-unit (CIU) analysis.
publication date2026-10-06
comparatorThe aim of this study was to investigate how word-finding difficulties can be detected and how they manifest themselves in connected speech in PwMS compared to non-brain-damaged (NBD) controls.
primary endpointThe aim of this study was to investigate how word-finding difficulties can be detected and how they manifest themselves in connected speech in PwMS compared to non-brain-damaged (NBD) controls.
findingsIn line with their own perceptions, word-finding difficulties were significantly more frequent in the MS group than in the NBD group (U = 144, p < .001).
limitationsTitle: Finding the right words in connected speech: An examination of word-finding difficulties in persons with multiple sclerosis.
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