Supervised Strength Training Programs in Human Subjects with Relapsing-Remitting MS

study phaseThis phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.

subjects"eligibilityCriteria": "Inclusion criteria include:\n\n* Women and men of reproductive age (18-45 years) with MS will be included, with the upper age limit adjusted to reflect the reproductive phase;\n* no iron-deficiency anemia;\n* stable disease phase;\n* independent walking ability for over 10 meters.\n\nWomen will be recruited first and later matched with men based on age, EDSS, and lifestyle habits (physical activity, smoking, and alcohol consumption).\n\nExclusion criteria will include participants with MS who:\n\n* score \\<1 or \\>6 on the EDSS;\n* report a relapse within 12 months before the study begins;\n* have taken corticosteroid treatment within the last 2 months;\n* have participated in a structured training program in the previous 6 months.\n\nOnce all women with MS are recruited, male participants will be recruited following a 1:1 matching methodology based on age, geographic region, and lifestyle habits.",

species"eligibilityCriteria": "Inclusion criteria include:\n\n* Women and men of reproductive age (18-45 years) with MS will be included, with the upper age limit adjusted to reflect the reproductive phase;\n* no iron-deficiency anemia;\n* stable disease phase;\n* independent walking ability for over 10 meters.\n\nWomen will be recruited first and later matched with men based on age, EDSS, and lifestyle habits (physical activity, smoking, and alcohol consumption).\n\nExclusion criteria will include participants with MS who:\n\n* score \\<1 or \\>6 on the EDSS;\n* report a relapse within 12 months before the study begins;\n* have taken corticosteroid treatment within the last 2 months;\n* have participated in a structured training program in the previous 6 months.\n\nOnce all women with MS are recruited, male participants will be recruited following a 1:1 matching methodology based on age, geographic region, and lifestyle habits.",

sample sizeA total of 75 participants will be randomly assigned to one of three groups: a supervised and individualized educational program focused on HIIT training, a supervised and individualized educational program focused on strength training, and a non-supervised, self-guided educational program based on resistance band training.

sample size basisA total of 75 participants will be randomly assigned to one of three groups: a supervised and individualized educational program focused on HIIT training, a supervised and individualized educational program focused on strength training, and a non-supervised, self-guided educational program based on resistance band training.

peer reviewedNo results are posted.

relevant ms types"eligibilityCriteria": "Inclusion criteria include:\n\n* Women and men of reproductive age (18-45 years) with MS will be included, with the upper age limit adjusted to reflect the reproductive phase;\n* no iron-deficiency anemia;\n* stable disease phase;\n* independent walking ability for over 10 meters.\n\nWomen will be recruited first and later matched with men based on age, EDSS, and lifestyle habits (physical activity, smoking, and alcohol consumption).\n\nExclusion criteria will include participants with MS who:\n\n* score \\<1 or \\>6 on the EDSS;\n* report a relapse within 12 months before the study begins;\n* have taken corticosteroid treatment within the last 2 months;\n* have participated in a structured training program in the previous 6 months.\n\nOnce all women with MS are recruited, male participants will be recruited following a 1:1 matching methodology based on age, geographic region, and lifestyle habits.",

intervention"description": "Participants will complete 36 strength sessions (3 times a week) at a moderate intensity, 6 educational nutritional intervention sessions, and 8 sessions on energy and fatigue management.",

comparator"description": "Participants will be involved in an unsupervised, self-directed program focusing on physical exercise (three times per week), nutrition and cognitive-behavioral habits.",

primary endpoint"description": "Satisfaction with Physical Activity will be measured using an eight-item, 5-point Likert scale",

follow upA control evaluation will be conducted three months after the intervention to assess the effects of the educational programs, followed by another evaluation three months later to analyze residual effects.

findings"briefSummary": "This phase of the project aims to compare in-person, supervised educational programs (EP) with online self-guided EPs in individuals with relapsing-remitting multiple sclerosis.

limitationsPlanned enrolment and endpoints are not findings.