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Research summary · 9 d ago

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MMP Genotype Associations with MS in Humans

A study with 200 participants found a strong association between the MMP2 rs243865 (-1306) TT genotype and multiple sclerosis (MS), with about 10 times higher odds of the disease. The MMP3 rs3025058 5A/6A genotype was also linked to 2.45 times higher odds of MS. Additionally, specific combinations of genotypes indicated even greater risks.

Tags: #MSResearch
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Source: Read original source (PMID 42882110)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Human efficacy: Not yet assessed
Mechanism: Not yet assessed
Evidence strength: Not yet assessed
Outcome: Not yet assessed

Why it matters

These findings highlight the potential genetic factors influencing MS susceptibility, suggesting a need for personalized approaches in MS management.

What this does not prove

The study did not find significant links between the genotypes and clinical factors such as attack frequency or disease duration, indicating that while genetics may influence susceptibility, they do not appear to directly affect disease progression.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Not reported
Participants / samples: 200 · basis not reported
Randomised: No
Controlled: Not reported
Primary endpoint met: No
Relevant MS type: Not reported
Publication date: 2026-10-02
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Not classified

Original sources

Primary evidenceGenetic Risk Factors of Neurodegeneration: The Role of MMP1 rs1799750 (-1607 1G/2G), MMP2 [rs243865 (-1306 C > T), rs2285053 (-735 C > T), and MMP3 rs3025058 (-1171 5A/6A) Genetic Variants in Multiple Sclerosis Pathogenesis. ↗DOI: 10.3390/jcm15197648

Supporting passages (6)

sample sizeMethods: The study included 100 MS patients and 100 healthy controls.

randomizedNo

primary endpoint metNo

publication date2026-10-02

findingsThe MMP2 rs243865 (-1306) TT genotype showed a strong positive association with MS, exhibiting approximately 10-fold higher odds of the disease (p < 0.001).

limitationsNo statistically significant association was found between the examined genotypes or haplotypes and clinical parameters, including attack frequency and disease duration (p > 0.05).

AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.