Higher NLR in MS-ON Patients Compared to Healthy Controls
A study with 135 participants found that the neutrophil-to-lymphocyte ratio (NLR) was significantly higher in patients with multiple sclerosis and optic neuritis (MS-ON) compared to healthy controls (2.83 vs. 1.80, p = 0.005). Additionally, NLR demonstrated moderate ability to differentiate MS-ON from controls (AUC 0.681).
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
These findings suggest that NLR may serve as a potential biomarker for MS-ON, but further research is needed to validate this association due to modest accuracy statistics.
What this does not prove
Caution is advised in interpreting these results, as modest ROC performance may limit reliability. Prospective validation is necessary to confirm these findings.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 135 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-10-11
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceSystemic inflammation in optic neuropathies: comparative insights from hematological and composite indices. ↗DOI: 10.1186/s12886-026-05433-0
Supporting passages (8)
comparatorCONCLUSIONS: In the primary analysis, NLR was the only index that retained significance after adjustment for age, sex, and multiple testing, with higher values in MS-ON than in healthy controls.
study designMETHODS: This retrospective study included 135 participants: 36 patients with MS-ON, 29 with NAION, 34 with IIH-ON, and 36 healthy controls.
subjectsMETHODS: This retrospective study included 135 participants: 36 patients with MS-ON, 29 with NAION, 34 with IIH-ON, and 36 healthy controls.
sample sizeMETHODS: This retrospective study included 135 participants: 36 patients with MS-ON, 29 with NAION, 34 with IIH-ON, and 36 healthy controls.
primary endpoint metCONCLUSIONS: In the primary analysis, NLR was the only index that retained significance after adjustment for age, sex, and multiple testing, with higher values in MS-ON than in healthy controls.
publication datePublication date: 2026-10-11
findingsCONCLUSIONS: In the primary analysis, NLR was the only index that retained significance after adjustment for age, sex, and multiple testing, with higher values in MS-ON than in healthy controls.
limitationsThe sensitivity of several other indices to robust inference and the modest ROC performance warrant cautious interpretation and prospective validation.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.