B-cell Subsets and Neurological Impairment in RRMS Patients
The study found that higher levels of certain B-cell subsets, including plasmablasts and memory CD27+CD38+ B cells, were positively correlated with increased neurological impairment and relapse rates in RRMS patients. Elevated CXCL13 levels were also noted in relapsed patients, reflecting a connection with specific B-cell characteristics.
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Why it matters
This information could aid in understanding the role of B-cell subsets in RRMS progression and relapses, potentially guiding future research and therapies.
What this does not prove
The findings indicate correlation rather than causation, which does not prove that these B-cell subsets directly influence relapse risk.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- RRMS
- Publication date
- Not reported
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceImbalance of Circulating B-Cell Subsets Was Associated With Higher Risk of Relapses in RRMS Patients. ↗DOI: 10.1155/jimr/7341319
Supporting passages (3)
relevant ms typesRRMS
findingsRESULTS: Here, the severity of neurological impairment positively correlated with the percentage of plasmablast (CD138+, IL-17+IL-10-, HLA-DR+IgD-) and memory CD27+CD38+B-cell subsets (IL-17+IL-10- and HLA-DR+IgD-), but negatively correlated with the proportion of HLA-DR-IgD+ and IL-17-IL-10+ among transitional and plasmablasts.
limitationsTitle: Imbalance of Circulating B-Cell Subsets Was Associated With Higher Risk of Relapses in RRMS Patients.
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