C57BL/6 Mice Study on Alcoholic Frankincense Extract and MS
In a preclinical study, female C57BL/6 mice were treated with alcoholic frankincense extract (200 mg/kg) for 33 days. This treatment improved clinical scores and body weight, reduced pro-inflammatory cytokines, enhanced antioxidant capacity, and reduced inflammatory damage in brain tissue compared to controls during EAE induced by MOG35-55/CFA.
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Why it matters
The findings suggest that alcoholic frankincense extract may have beneficial effects on inflammation and myelin integrity in a mouse model of MS, warranting further research.
What this does not prove
The study's limitations include the need for further validation of results and evaluation of clinical applicability.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Laboratory
- Participants / samples
- 15 · 5 mice per group
- Randomised
- Yes
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceInvestigation of the effects of alcoholic frankincense extract on oxidative stress and inflammatory parameters in C57BL/6 mice with induced autoimmune encephalomyelitis. ↗DOI: 10.22038/ajp.2026.27390
Supporting passages (14)
study phaseThis study aimed to evaluate the therapeutic effects of alcoholic frankincense extract in an experimental model of MS.
study designExperimental autoimmune encephalomyelitis (EAE) was induced by subcutaneous immunization with MOG35-55/CFA and intraperitoneal injection of pertussis toxin.
subjectsFemale C57BL/6 mice were randomly assigned to three groups (n = 5).
speciesExperimental autoimmune encephalomyelitis (EAE) was induced by subcutaneous immunization with MOG35-55/CFA and intraperitoneal injection of pertussis toxin.
sample sizeMATERIALS AND METHODS: Female C57BL/6 mice were randomly assigned to three groups (n = 5).
sample size basisMATERIALS AND METHODS: Female C57BL/6 mice were randomly assigned to three groups (n = 5).
randomizedMATERIALS AND METHODS: Female C57BL/6 mice were randomly assigned to three groups (n = 5).
peer reviewedJournal: Avicenna journal of phytomedicine
primary endpoint metFrankincense treatment significantly improved clinical scores and body weight, decreased proinflammatory cytokines, enhanced antioxidant capacity, and attenuated inflammatory infiltration and myelin degradation in brain tissue.
interventionMice were treated orally with alcoholic frankincense extract (200 mg/kg) for 33 days.
primary endpointSerum levels of IL-17A, IL-23, transforming growth factor-β (TGF-β), and total antioxidant capacity (TAC) were measured, and brain tissues were examined histopathologically.
follow upMice were treated orally with alcoholic frankincense extract (200 mg/kg) for 33 days.
findingsEAE induction caused significant weight loss, severe clinical symptoms, increased IL-17A and IL-23 levels, reduced TGF-β and TAC, and marked neuroinflammation with myelin damage.
limitationsFurther studies are warranted to confirm its clinical applicability.
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