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Research summary · 5 h ago

AI summary · not yet reviewedHuman studyNot reportedPublished in a peer-reviewed journal

Cognitive Domains and Balance Performance in Ambulatory Individuals with MS

In a study involving 54 ambulatory individuals with MS, it was found that processing speed was linked to balance sway in less challenging conditions (eyes open, feet apart). In more difficult conditions (eyes closed), factors like attention and fear of falling became significant predictors of balance performance.

Tags: #MSResearch
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Source: Read original source (PMID 42953447)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Human efficacy: Not established from this source
Mechanism: Not reported
Evidence strength: Not graded
Outcome: Not reported

Why it matters

These findings suggest that specific cognitive functions, such as processing speed and attention, may play a role in balance performance among individuals with MS, highlighting the relationship between cognitive and motor functions in mobility.

What this does not prove

The study emphasizes that while cognition and balance have been studied broadly, there is a lack of research on how specific cognitive domains relate to balance under varying challenges.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Not reported
Participants / samples: Not reported
Randomised: Not reported
Controlled: Not reported
Primary endpoint met: Not reported
Relevant MS type: Not reported
Publication date: 2026-08-31
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Not classified
Biological target: Not reported
Pathway: Not reported
Population: Ambulatory individuals with MS
Size of effect: Not reported
Secondary endpoints: Not reported
MRI endpoints: Not reported
Biomarkers: Not reported
Safety: Not reported

Original sources

Primary evidenceDomain-Specific Cognitive Associations With Standing Balance in Multiple Sclerosis. ↗DOI: 10.7224/1537-2073.2025-069

Supporting passages (7)

sample size basisMETHODS: Fifty-four ambulatory individuals with MS completed 4 standing balance tasks that increased in difficulty by altering visual input (eyes open/closed) and stance (feet apart/together).

publication date2026-08-31

findingsProcessing speed (SDMT) was significantly associated with sway during the least complex condition (eyes open, feet apart). Under more challenging conditions (eyes closed), attention (TMT-A) and concern about falling (FES-I) emerged as significant predictors of balance performance.

limitationsAlthough prior studies have examined global cognition and balance, few have investigated the relation between specific cognitive domains and balance performance under progressively challenging static conditions.

populationMETHODS: Fifty-four ambulatory individuals with MS completed 4 standing balance tasks that increased in difficulty by altering visual input (eyes open/closed) and stance (feet apart/together).

peer reviewedPublication types: Journal Article

subjectsMETHODS: Fifty-four ambulatory individuals with MS completed 4 standing balance tasks that increased in difficulty by altering visual input (eyes open/closed) and stance (feet apart/together).

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