Chronic Lower Limb Edema in Humans with Multiple Sclerosis
In a study of 238 people with MS, the self-reported prevalence of chronic lower limb edema (CLLE) was 42.4%, while clinical assessment found it to be 61.9%. Those with CLLE had poorer quality of life scores and a higher incidence of cellulitis (14% vs. 2%).
- Tags
- #Other
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Positive
Why it matters
Understanding the prevalence of CLLE helps recognize its commonality in MS and highlight its impact on quality of life, although it may often go unrecognized by patients.
What this does not prove
The study does not establish direct causation due to uncontrolled evaluation of potential factors like age and mobility, and self-reported data may underestimate CLLE prevalence.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 238 · self-reported participants with chronic lower limb edema
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-10-19
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- people with MS experiencing chronic lower limb edema
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Higher incidence of cellulitis in those with CLLE (14% compared with 2%).
Original sources
- Primary evidenceChronic Lower Limb Edema in People with Multiple Sclerosis: Prevalence, Cause and Impact. ↗DOI: 10.1177/15578585261496094
Supporting passages (15)
study phaseChronic Lower Limb Edema in People with Multiple Sclerosis: Prevalence, Cause and Impact.
study designChronic Lower Limb Edema in People with Multiple Sclerosis: Prevalence, Cause and Impact.
subjectsThe aims of the study were to determine the prevalence and possible causative factors of CLLE in people with MS, and to examine the impact of CLLE on participants' quality of life.
sample sizeThe self-reported prevalence of CLLE was 42.4% (101/238).
sample size basis238
peer reviewedJournal Article
primary endpoint metThe aims of the study were to determine the prevalence and possible causative factors of CLLE in people with MS, and to examine the impact of CLLE on participants' quality of life.
publication datePublication date: 2026-10-19
primary endpointMETHODS AND RESULTS: The prevalence of CLLE was determined by questionnaire (i.e., self-reported) and by clinical examination.
findingsIn those with CLLE, scores in the function, appearance, and symptom domains of LYMQOL demonstrated a poorer quality of life.
populationTitle: Chronic Lower Limb Edema in People with Multiple Sclerosis: Prevalence, Cause and Impact.
outcomeCLLE is a common problem is people with MS but may not always be recognized by patients.
safety signalsThere was a higher incidence of cellulitis in those with CLLE (14% compared with 2%).
limitationsTitle: Chronic Lower Limb Edema in People with Multiple Sclerosis: Prevalence, Cause and Impact.
peer reviewedPublication types: Journal Article
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