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Research summary · 8 d ago

AI summary · not yet reviewedHuman studyObservationalPublished in a peer-reviewed journal

Observational Study on Multiple Sclerosis and Normal Pressure Hydrocephalus in Human Subjects

A study involving 36 patients with multiple sclerosis (MS) and normal pressure hydrocephalus (NPH) found that gait disorders were common, with 83% experiencing bladder dysfunction and 67% cognitive dysfunction. Following ventriculoperitoneal shunt surgery, 58% showed gait improvement post-high-volume tap test, and 83% improved post-surgery.

Tags: #MSResearch
Most relevant to: —
Source: Read original source (PMID 42887227)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Human efficacy: Not yet assessed
Mechanism: Not yet assessed
Evidence strength: Not yet assessed
Outcome: Not yet assessed

Why it matters

These findings highlight a significant overlap between MS and NPH, emphasizing the need for careful diagnosis and the potential for surgical interventions in affected patients.

What this does not prove

The retrospective nature of the study limits the ability to establish causation, and the small sample size may affect the generalizability of the results.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Observational
Participants / samples: 36 · basis not reported
Randomised: Not reported
Controlled: Not reported
Primary endpoint met: Not reported
Relevant MS type: RRMS, SPMS, PPMS
Publication date: 2026-10-08
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Not classified

Original sources

Primary evidenceNormal pressure hydrocephalus in people with multiple sclerosis. ↗DOI: 10.1016/j.msard.2026.107959

Supporting passages (9)

study designRetrospective Mayo Clinic database review of "MS" and "NPH" and "Gait disorder" 1996-2025.

subjectsThirty-six pwMS and INPH were included.

sample sizeThirty-six pwMS and INPH were included.

peer reviewedJournal: Multiple sclerosis and related disorders

relevant ms typesNineteen (53%) had secondary progressive MS; 10 (28%), relapsing-remitting and 7 (19%), primary progressive MS.

publication datePublication date: 2026-10-08

interventionINPH was defined as possible (≥2 INPH triad and ventriculomegaly), probable (possible INPH with Disproportionately Enlarged Sub-arachnoid space Hydrocephalus [DESH] or positive high-volume tap test [HVTT]) and definite (gait improvement following ventriculoperitoneal [VP] shunt).

findingsAll had INPH gait disorder, 30 (83%) bladder dysfunction, 24 (67%) cognitive dysfunction and 20 (56%) with full INPH triad.

limitationsTitle: Normal pressure hydrocephalus in people with multiple sclerosis.

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