Unknown Subjects in Gut Microbial Products and Sex Hormones in MS
A systematic review was conducted to investigate the role of gut microbial products in the pathogenesis of multiple sclerosis (MS) and to explore the impact of sex hormones on this process. It introduced the concept of the "microgenderome" that connects gut microbiota and hormonal influence.
- Tags
- #ImmuneReset
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding the relationship between gut microbiota, hormonal influences, and MS could provide insights into disease mechanisms and potential avenues for future research.
What this does not prove
The review lacks clinical trial results, making it unclear how these findings relate to specific interventions or outcomes in patients.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-08
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Immune reset, Other
Original sources
- Primary evidenceMultiple sclerosis occurrence with gut microbial metabolites and sex hormones. ↗DOI: 10.1016/j.msard.2026.107973
Supporting passages (5)
study designThis review focuses on identifying the role of specific gut microbial products (short-chain fatty acids, tryptophan derivatives, bile acids, and polyamines) in this process and how they affect the immune system, blood-brain barrier (BBB), and glial cells.
research categoriesThis paper discusses the intersection of these ideas through the "microgenderome" concept, which describes how hormones influence gut microbiota composition and how the microbiota, in turn, modulates hormone metabolism and levels.
publication date2026-10-08
findingsThis review focuses on identifying the role of specific gut microbial products (short-chain fatty acids, tryptophan derivatives, bile acids, and polyamines) in this process and how they affect the immune system, blood-brain barrier (BBB), and glial cells.
limitationsTitle: Multiple sclerosis occurrence with gut microbial metabolites and sex hormones.
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