Neuronal Hyperexcitability and Neuropathic Pain in Multiple Sclerosis: Insights from Systematic Review
This systematic review highlights that neuropathic pain significantly lowers quality of life in multiple sclerosis (MS) and identifies neuronal hyperexcitability as its main driver, resulting from various interacting cellular events.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Moderate
- Outcome
- Not reported
Why it matters
Understanding the mechanisms behind neuropathic pain in MS is critical for addressing symptoms that affect patient quality of life, yet the impact of recent classifications distinguishing neuropathic from nociplastic pain is not fully understood.
What this does not prove
The review does not clarify the implications of this new pain classification on MS-related neuropathic pain models.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not applicable
- Controlled
- Not applicable
- Primary endpoint met
- Not applicable
- Relevant MS type
- Not reported
- Publication date
- 2026-10-31
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidencePathophysiology of Neuropathic Pain in Multiple Sclerosis: a Review. ↗DOI: 10.1007/s12035-026-06304-x
Supporting passages (11)
study designPublication types: Journal Article; Review
subjectsMeSH terms: Humans; Multiple Sclerosis; Neuralgia; Animals; Nociplastic Pain
publication datePublication date: 2026-10-31
findingsNeuropathic pain is one of the most relevant symptoms in multiple sclerosis (MS) and is a key contributor to the impaired quality of life in this disease.
findingsAt the molecular and cellular scale, neuronal hyperexcitability is the main driver of neuropathic pain; it is the final consequence of other interacting events taking place on the cell membrane and in the intracellular and extracellular environment.
limitationsMoreover, in recent years a distinction has been drawn between neuropathic and nociplastic pain; the consequences of this new classification on pathophysiological models of MS-related neuropathic pain are not still fully understood and deserve future attention.
peer reviewedPublication types: Journal Article; Review
study phasePublication types: Journal Article; Review
randomizedPublication types: Journal Article; Review
controlledPublication types: Journal Article; Review
primary endpoint metPublication types: Journal Article; Review
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