Measurement Properties of WHODAS 2.0 in Adults with MS
A systematic review analyzed 28 reports on the WHODAS 2.0 in adults with MS. Moderate-certainty evidence indicated it has reliability and construct validity. Associations with quality of life and clinical severity had low-certainty evidence, while evidence on fatigue, mood, cognition, participation, and employment was of low to very low certainty. Comparisons were challenging due to varying methods and overlapping cohorts.
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Why it matters
This review highlights WHODAS 2.0 as a useful tool for measuring disability in MS, emphasizing its reliability. However, the weak evidence base for treatment responses necessitates caution in claims about its clinical utility.
What this does not prove
Most studies were cross-sectional, leading to limitations in understanding longitudinal effects. There was a lack of standardization in metrics and scoring methods, and the findings suggested measurement use but not treatment efficacy.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- 28 · number of reports included
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-02
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Other
Original sources
- Primary evidenceThe Measurement Properties and Applications of WHODAS 2.0 in Multiple Sclerosis: A Systematic Review. ↗DOI: 10.3390/medsci14050542
Supporting passages (12)
primary endpointmeasurement properties and applications
study designThis systematic review evaluated the measurement properties and applications of the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in adults with MS across research and clinical contexts.
subjectsEligible peer-reviewed studies reported extractable WHODAS data in adults with MS.
sample sizeOf the 677 records identified, 28 reports were included.
sample size basisResults: Of the 677 records identified, 28 reports were included.
peer reviewedEligible peer-reviewed studies reported extractable WHODAS data in adults with MS.
research categoriesEvidence was organized into measurement, clinical-association, participation/employment, intervention, digital-monitoring, and longitudinal streams.
publication date2026-09-02
interventionWHODAS 2.0
comparatorExpanded Disability Status Scale
findingsEvidence supports measurement use more strongly than prognostic, treatment-response, or benefit-determination claims.
limitationsStandardized version selection, scoring, domain reporting, and prespecified longitudinal endpoints are required.
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