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Research summary · 4 d ago

AI summary · not yet reviewedHuman studyNot reportedPublished in a peer-reviewed journal

Studies on Sudomotor Dysfunction in People with MS

A review of 27 studies on 1,317 individuals with multiple sclerosis (MS) assessed the prevalence of sudomotor dysfunction. Findings indicated that 33.0% exhibited symptoms based on questionnaires and 35.0% showed objective testing results. The absence of sympathetic skin response was notably 33.6% in MS patients, significantly more frequent compared to healthy controls with an odds ratio of 24.13.

Tags: #MSResearch
Most relevant to: —
Source: Read original source (PMID 42901055)

This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.

Human efficacy: Not established from this source
Mechanism: Not reported
Evidence strength: Not graded
Outcome: Not reported

Why it matters

Understanding the prevalence of sudomotor dysfunction in MS can help raise awareness about this potential complication and improve diagnosis and management strategies for affected individuals.

What this does not prove

The evidence regarding the prevalence from objective testing is of very low certainty, meaning the findings should be interpreted cautiously.

Next milestone

No next milestone was established from the available source.

Study facts

Study design: Not reported
Participants / samples: 1317 · Twenty-seven studies including 1317 people with MS were included.
Randomised: Not reported
Controlled: Not reported
Primary endpoint met: Not reported
Relevant MS type: RRMS, PPMS
Publication date: 2026-10-18
Evidence reviewed: Abstract only
Regulatory approval: Not reported
Research areas: Not classified
Biological target: Not reported
Pathway: Not reported
Population: Not reported
Size of effect: Not reported
Secondary endpoints: Not reported
MRI endpoints: Not reported
Biomarkers: Not reported
Safety: Not reported

Original sources

Primary evidenceSudomotor dysfunction in multiple sclerosis: A systematic review and meta-analysis. ↗DOI: 10.1016/j.msard.2026.108006

Supporting passages (10)

sample size1317

sample size basisTwenty-seven studies including 1317 people with MS were included.

relevant ms typesObjective dysfunction was more frequent in PMS than RRMS (60/104 vs 35/104; OR 3.12, 95% CI 1.71-5.68; I²=0%).

publication date2026-10-18

comparatorhealthy controls

primary endpointprevalence of sudomotor dysfunction

findingsAbsent sympathetic skin response had a pooled prevalence of 33.6% (95% CI 26.1-42.1%) and was more frequent in MS than in healthy controls (160/461 vs 0/342; OR 24.13, 95% CI 10.71-54.39; I²=0%).

limitationsCertainty of evidence for objective prevalence was very low.

peer reviewedPublication types: Journal Article

subjectsMETHODS: PubMed, Scopus, and Web of Science were searched from inception through June 9, 2026, for studies reporting sudomotor dysfunction in adults with MS using history/questionnaires or objective testing.

AI assessment, not yet reviewed by a person · version 2 · Community votes are separate from evidence review.