Type-I and Type-II IFNs Required for T Cell Infiltration in EAE Model
A study found that type-I and type-II interferons (IFNs) are necessary for T cells to enter the brain in an experimental autoimmune encephalomyelitis (EAE) model, which simulates multiple sclerosis. The signaling from type-I IFNs influences synaptic and metabolic activities in neurons and astrocytes.
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- #MSResearch
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Why it matters
Understanding the role of IFNs could provide insights into the mechanisms of T cell activity in brain inflammation, which is relevant for multiple sclerosis pathology.
What this does not prove
This study does not demonstrate clinical efficacy for targeting IFN responses in MS; it solely explores pathological mechanisms in the EAE model.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-25
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceType-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain. ↗DOI: 10.64898/2026.09.23.753833
Supporting passages (4)
publication date2026-09-25
findingsMoreover, both type-I and type-II IFNs are required for T cells to infiltrate the brain and initiate an IFN response associated with synaptic and metabolic programs in neurons and astrocytes in the cortex and hippocampus.
findingsMoreover, both type-I and type-II IFNs are required for T cells to infiltrate the brain and initiate an IFN response associated with synaptic and metabolic programs in neurons and astrocytes in the cortex and hippocampus.
limitationsTitle: Type-I IFNs in EAE drive synaptic transcriptional responses in neurons and astrocytes in the brain.
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