Human Study on Lymphangioleiomyomatosis (LAM) Pathogenesis
This study aims to define the clinical course and pathogenesis of LAM at cellular and molecular levels. It focuses on identifying proteins and genes linked to lung destruction in affected individuals. Currently, there are no posted results as the study is ongoing.
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- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding the cellular and molecular underpinnings of LAM can lead to the development of more effective therapies. Currently, treatment options are limited and prognosis is poor, making this research potentially significant for future advancements in care.
What this does not prove
No results are available. The study is designed but findings on enrollment and endpoints are not yet posted, meaning associations or causal relationships cannot be inferred.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- No
- Controlled
- Not applicable
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Trial registry record
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Trial registrationStudy of the Disease Process of Lymphangioleiomyomatosis ↗
Supporting passages (8)
subjects"description": "Patients with tissue diagnosis of LAM may be admitted for evaluation every six months, or as deemed necessary for research",
randomizedIf there is concern for abuse, coercion, exploitation, or danger, the study team will follow applicable mandatory reporting laws and institutional policies, including notification of appropriate authorities and/or a parent or guardian when required to protect the participant or as otherwise required.\n\nProcedures that will not be completed while the subject is pregnant and/or nursing include: Arterial Blood Gases (ABG), HIV testing, treadmill test, lung biopsy, thoracentesis, bronchoscopy, and measurements with imaging modalities requiring contrast or with radiation exposure such as Chest x-ray, CT scan, MRI with or without contrast, lung scan, bone densitometry (DEXA).
controlledIf there is concern for abuse, coercion, exploitation, or danger, the study team will follow applicable mandatory reporting laws and institutional policies, including notification of appropriate authorities and/or a parent or guardian when required to protect the participant or as otherwise required.\n\nProcedures that will not be completed while the subject is pregnant and/or nursing include: Arterial Blood Gases (ABG), HIV testing, treadmill test, lung biopsy, thoracentesis, bronchoscopy, and measurements with imaging modalities requiring contrast or with radiation exposure such as Chest x-ray, CT scan, MRI with or without contrast, lung scan, bone densitometry (DEXA).
peer reviewedPublication date: unknown.
intervention"Device: Toshibia Aquilion One CT"
primary endpointThis study is designed to (a) define the clinical course of the disease and (b) elucidate the pathogenesis of the disease at the cellular and molecular levels, in order to develop more effective therapy.
findingsCurrently, there is no effective therapy for the disease and the prognosis is poor.\n\nThis study is designed to determine the disease processes involved at the level of cells and molecules, in order to develop more effective therapy.\n\nResearchers intend to identify the proteins and genes that contribute to the process of lung destruction in affected individuals.",
limitationsNo results are posted. Planned enrolment and endpoints are not findings.
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