Eye Movement Study in Human Subjects with Multiple Sclerosis
This study assessed 86 individuals with multiple sclerosis (PwMS) over 12 months and found that they initially had slower response times and increased eye movement errors compared to healthy controls. After a year of frequent oculomotor tasks, PwMS improved their performance on specific eye movement tests, showing significant increases in correct responses.
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- #MSResearch
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Why it matters
These findings suggest that repeated exposure to oculomotor tasks may enhance eye movement control in PwMS, reflecting potential for cognitive training approaches. However, the specific influence of such tasks remains partially understood.
What this does not prove
The study notes a lack of longitudinal data on eye movement abnormalities in PwMS, making the precise impact of repeated testing on performance unclear.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 86 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-10-07
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceTraining effects in oculography in multiple sclerosis patients: a one-year longitudinal study. ↗DOI: 10.1007/s00417-026-07540-6
Supporting passages (11)
study designprospectively assessed using infrared oculography (DEMoNS protocol)
subjects86 PwMS and 22 healthy controls (HCs, baseline, and 3 months only) were prospectively assessed
sample size86
primary endpoint metAt 12 months PwMS showed increased performance in anti-saccades (correct responses + 9%, P < 0.001) and double-step saccades (correct responses + 8%, P < 0.001; error - 0.39°, P < 0.001).
publication date2026-10-07
interventionCONCLUSIONS: Frequent oculomotor tasks may induce training effects in complex oculography tasks, such as anti-saccades and double-step saccades.
comparatorcompared to HCs
primary endpointto determine whether frequent exposure to eye movement tasks influences these measurements
follow up12 months
findingsAt baseline PwMS showed increased 15° latency (+ 18ms, P = 0.029) and versional dysconjugacy (index + 0.08, P = 0.028) on pro-saccades compared to HCs.
limitationsquantitative data on eye movement abnormalities in people with multiple sclerosis (PwMS) are scarce, and the impact of repeated oculomotor testing on these measures is unknown.
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