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Research summary · AI summary · not yet reviewedHuman studyLaboratoryPublished in a peer-reviewed journal
Higher Arterial Stiffness in People with MS Compared to Controls
A study involving 129 people with multiple sclerosis (MS) found they had higher arterial stiffness compared to 51 control subjects. This difference remained significant even after controlling for factors like age, BMI, and mental health.
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- #MSResearch
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This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
- Human efficacy
- Demonstrated in people
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Positive
Why it matters
Understanding arterial stiffness in MS patients is crucial as it may indicate cardiovascular risks and contribute to overall health outcomes. This finding emphasizes the need to investigate cardiovascular health in people with MS.
What this does not prove
The study did not account for potential confounding factors such as the effects of medications on arterial stiffness in MS patients.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Laboratory
- Participants / samples
- 129 · basis not reported
- Randomised
- Not reported
- Controlled
- Yes
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-07-06
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- 129 people with MS (age, 48.5 years; median EDSS score 4)
- Size of effect
- d = -0.0354 for arterial stiffness
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceArterial Stiffness Is Higher in People With Multiple Sclerosis Than in Control Group. ↗DOI: 10.7224/1537-2073.2024-108
Supporting passages (12)
study designThis study examined the difference in arterial stiffness between people with MS and controls and whether the difference was accounted for by anxiety, depression, and walking endurance, variables not usually included in other studies of arterial stiffness in MS.
subjectsMETHODS: The sample included 129 people with MS (age, 48.5 [10.8] years; 70.5% female; Expanded Disability Status Scale score median, 4) and 51 controls without MS (age, 48.7 [11.3] years; 78.4% female) who completed arterial stiffness, anxiety, and depression assessments and the 6-Minute Walk Test (6MWT).
sample sizeMETHODS: The sample included 129 people with MS (age, 48.5 [10.8] years; 70.5% female; Expanded Disability Status Scale score median, 4) and 51 controls without MS (age, 48.7 [11.3] years; 78.4% female) who completed arterial stiffness, anxiety, and depression assessments and the 6-Minute Walk Test (6MWT).
controlledThis study examined the difference in arterial stiffness between people with MS and controls and whether the difference was accounted for by anxiety, depression, and walking endurance, variables not usually included in other studies of arterial stiffness in MS.
populationMETHODS: The sample included 129 people with MS (age, 48.5 [10.8] years; 70.5% female; Expanded Disability Status Scale score median, 4) and 51 controls without MS (age, 48.7 [11.3] years; 78.4% female) who completed arterial stiffness, anxiety, and depression assessments and the 6-Minute Walk Test (6MWT).
findingsCONCLUSIONS: Our results indicate that people with MS have higher levels of arterial stiffness compared with controls, but this difference is not explained by age, BMI, MAP, anxiety, depression, or walking endurance.
outcomeCONCLUSIONS: Our results indicate that people with MS have higher levels of arterial stiffness compared with controls, but this difference is not explained by age, BMI, MAP, anxiety, depression, or walking endurance.
effect sizeThe difference in arterial stiffness between groups remained when controlling for age, BMI, MAP, anxiety and depression symptoms, and 6MWT distance.
human efficacyCONCLUSIONS: Our results indicate that people with MS have higher levels of arterial stiffness compared with controls, but this difference is not explained by age, BMI, MAP, anxiety, depression, or walking endurance.
publication datePublication date: 2026-07-06
limitationsTitle: Arterial Stiffness Is Higher in People With Multiple Sclerosis Than in Control Group.
peer reviewedPublication types: Journal Article
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