Cognitive Associations in Adults with Multiple Sclerosis: MRI Findings
In a cross-sectional study of 25 adults with multiple sclerosis, researchers assessed cognitive performance through the Montreal Cognitive Assessment and analyzed MRI data. They found weak correlations between total T2/FLAIR lesion burden and cognitive function, with the strongest association seen between infratentorial lesions and concentration, as well as global brain atrophy and visuospatial performance, but none remained significant after adjustments for multiple comparisons.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
These findings suggest a complex relationship between MRI markers and cognitive performance in multiple sclerosis, highlighting the need for further research into how these factors may interact. Understanding this relationship is crucial for improving care and outcomes in MS patients.
What this does not prove
The study did not find statistically significant associations after correcting for multiple comparisons, which limits the conclusions that can be drawn. Additionally, the definitions and measures of cognitive dysfunction and MRI correlations are still not fully established.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 25 · Number of adults with clinically confirmed multiple sclerosis
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Adults with clinically confirmed multiple sclerosis
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceConventional MRI Markers and Cognitive Dysfunction in Multiple Sclerosis: An Exploratory Pilot Study. ↗DOI: 10.1002/brb3.71868
Supporting passages (10)
study designMETHODS: In this exploratory cross-sectional study, 25 adults with clinically confirmed multiple sclerosis underwent cognitive assessment using the standard Persian Montreal Cognitive Assessment (MoCA), version 7.1, and conventional 1.5-T brain MRI.
subjectsTwenty-five patients with clinically confirmed MS completed cognitive and MRI assessments.
sample sizeTwenty-five patients with clinically confirmed MS completed cognitive and MRI assessments.
sample size basisMETHODS: In this exploratory cross-sectional study, 25 adults with clinically confirmed multiple sclerosis underwent cognitive assessment using the standard Persian Montreal Cognitive Assessment (MoCA), version 7.1, and conventional 1.5-T brain MRI.
populationMETHODS: In this exploratory cross-sectional study, 25 adults with clinically confirmed multiple sclerosis underwent cognitive assessment using the standard Persian Montreal Cognitive Assessment (MoCA), version 7.1, and conventional 1.5-T brain MRI.
findingsPeriventricular (88%) and juxtacortical/cortical (84%) lesions were the most frequent MRI findings, total T2/FLAIR lesion burden showed only weak correlations with cognitive performance (ρ range -0.02 to 0.29; all FDR-adjusted p > 0.65).
limitationsINTERPRETATION: Although no MRI-cognitive association remained statistically significant after correction for multiple comparisons, several unadjusted associations showed moderate effect sizes and may warrant further investigation.
peer reviewedPublication types: Journal Article
subjectsMeSH terms: Humans; Magnetic Resonance Imaging; Female; Multiple Sclerosis; Pilot Projects; Cross-Sectional Studies; Cognitive Dysfunction; Adult; Male; Middle Aged; Atrophy; Brain
study designMeSH terms: Humans; Magnetic Resonance Imaging; Female; Multiple Sclerosis; Pilot Projects; Cross-Sectional Studies; Cognitive Dysfunction; Adult; Male; Middle Aged; Atrophy; Brain
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