Human MS Patients Undergoing High-Efficacy Therapy
In a study of 37 participants, including treatment-naïve relapsing MS patients and healthy controls, researchers found altered tissue microstructure in MS patients compared to controls. After three months of high-efficacy therapy, lesions showed increased fiber ratios but reduced cell ratios in gray matter and lesions.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
These findings highlight the potential for diffusion MRI to reveal early treatment impacts in MS and distinguish between patient subtypes, aiding in understanding disease progression and management.
What this does not prove
This study does not establish long-term treatment efficacy or its applicability beyond the specific cohorts involved.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 37 · total number of participants
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- RRMS, SPMS
- Publication date
- 2026-10-13
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceDiffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis. ↗DOI: 10.1002/acn3.70546
Supporting passages (13)
study designMETHODS: Thirty-seven participants underwent multi-shell diffusion MRI: 11 healthy controls, 15 treatment-naïve relapsing, and 11 non-relapsing patients.
subjectsThirty-seven participants underwent multi-shell diffusion MRI: 11 healthy controls, 15 treatment-naïve relapsing, and 11 non-relapsing patients.
speciesThirty-seven participants underwent multi-shell diffusion MRI: 11 healthy controls, 15 treatment-naïve relapsing, and 11 non-relapsing patients.
sample sizeMETHODS: Thirty-seven participants underwent multi-shell diffusion MRI: 11 healthy controls, 15 treatment-naïve relapsing, and 11 non-relapsing patients.
sample size basisMETHODS: Thirty-seven participants underwent multi-shell diffusion MRI: 11 healthy controls, 15 treatment-naïve relapsing, and 11 non-relapsing patients.
relevant ms typesLesional cell ratio was higher in relapsing than non-relapsing patients at the core (p = 0.03) and rim (p = 0.04) but not perilesionally; treatment-related improvement was similar across compartments.
publication datePublication date: 2026-10-13
interventionINTERPRETATION: Diffusion basis spectrum imaging distinguishes relapsing from non-relapsing disease by lesion-body cellularity and detects treatment-related changes in fiber and cell compartments.
comparatorRESULTS: Treatment-naïve relapsing patients showed reduced normal-appearing white matter fiber (p = 0.04) and elevated hindered ratios (p = 0.02) versus controls.
primary endpointTitle: Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis.
follow upThirteen were rescanned ~3 months after starting high-efficacy disease-modifying therapy.
findingsAfter treatment, lesional fiber ratio increased (p = 0.01) while lesional and gray matter cell ratios declined (both p = 0.02).
limitationsTitle: Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis.
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