Spatial Omics in Neuroinflammation Studies
A systematic review discussed spatial omics technologies revealing that neuroinflammation clusters around specific structures like amyloid plaques and demyelinated lesions. These studies identified glial niches associated with plaques and lipid-iron enriched rims around lesions.
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- #MSResearch
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Why it matters
Understanding how neuroinflammation is organized has implications for targeting therapies in diseases like multiple sclerosis. However, current findings are limited by resolution and functional validation constraints, which affect the direct applicability to humans.
What this does not prove
Existing spatial maps are constrained by resolution and the suitability of human tissue, lacking sufficient functional validation.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-07
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceSpatial omics of neuroinflammation: insights across brain diseases. ↗DOI: 10.3389/fimmu.2026.1923995
Supporting passages (4)
study designIn this review, we summarize major spatial transcriptomic, proteomic, metabolomic and same-section multi-omic technologies, with emphasis on the types of neuroinflammatory questions each platform can answer.
findingsAcross these settings, spatial studies have revealed plaque-associated glial niches, lipid- and iron-enriched lesion rims, core-penumbra inflammatory zonation, and hypoxic or perivascular immune microenvironments.
limitationsFinally, we discuss the limitations of current spatial maps, including resolution, human tissue constraints and insufficient functional validation, and outline future directions toward integrated, temporal and clinically translatable spatial atlases.
publication datePublication date: 2026-09-07
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