Neutrophil Heterogeneity in Mouse Model of Multiple Sclerosis
In a study using the EAE model, it was found that neutrophils in the spleen and bone marrow gain both CD4+ T cell suppressive capabilities and promote Th17 responses. Different neutrophil subsets were identified, with specific subsets showing immunosuppressive or pro-inflammatory activities, heavily influenced by the tissue environment.
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Why it matters
This research highlights the complexity of neutrophil responses in autoimmune conditions and may inform future studies on immune regulation in diseases like MS.
What this does not prove
The study does not establish direct implications for human MS beyond observation in patients.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Laboratory
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-22
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Neuroinflammation, Other
Original sources
- Primary evidenceSingle-cell transcriptomics reveal tissue-specific neutrophil heterogeneity and functional reprogramming in autoimmunity. ↗DOI: 10.1016/j.jaut.2026.103637
Supporting passages (8)
study phaseHere, using experimental autoimmune encephalomyelitis (EAE), we show that splenic and bone marrow neutrophils acquire both CD4+ T cell suppressive and Th17-promoting capacities.
study designNeutrophils are increasingly recognized as key regulators of autoimmune responses; however, the mechanisms by which their heterogeneity is influenced across various tissues in autoimmunity remain insufficiently understood.
subjectsHere, using experimental autoimmune encephalomyelitis (EAE), we show that splenic and bone marrow neutrophils acquire both CD4+ T cell suppressive and Th17-promoting capacities.
peer reviewedJournal: Journal of autoimmunity
research categoriesCollectively, our findings illustrate that splenic extramedullary granulopoiesis creates a heterogeneous neutrophil landscape, which is further shaped by tissue-specific microenvironments, driving the functional plasticity of neutrophils in EAE.
publication datePublication date: 2026-09-22
findingsCollectively, our findings illustrate that splenic extramedullary granulopoiesis creates a heterogeneous neutrophil landscape, which is further shaped by tissue-specific microenvironments, driving the functional plasticity of neutrophils in EAE.
limitationsTitle: Single-cell transcriptomics reveal tissue-specific neutrophil heterogeneity and functional reprogramming in autoimmunity.
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