Intravitreal voriconazole injections in a case of Quambalaria endophthalmitis
A single case report described a patient with Quambalaria, a rare ocular pathogen causing severe eye infection. Despite initial treatments, the infection worsened until a series of intravitreal voriconazole injections helped control it, preserving the eye, but resulting in only light perception as the final vision outcome.
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Why it matters
This case highlights Quambalaria as a serious but rare cause of endophthalmitis, and it showcases the potential of voriconazole in treating such infections, though conclusions should be cautious given the single case basis.
What this does not prove
Findings are limited to a single patient, preventing broader conclusions about Quambalaria infections in multiple sclerosis or the generalizability of treatment effectiveness.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Case report
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceOpportunistic Quambalaria fungal endophthalmitis in fumarate-treated multiple sclerosis complicated by multifocal postinfectious cerebral vasculopathy. ↗DOI: 10.1097/icb.0000000000001987
Supporting passages (7)
study phaseMETHODS: Single-patient case report.
study designSingle-patient case report.
sample size basisMETHODS: Single-patient case report.
interventionA route of infection could not be established with certainty: a preceding ocular injury with plant material and an earlier lower-limb cellulitis each offered a plausible mechanism Despite intravitreal anti-fungal therapy, two pars plana vitrectomies and systemic antifungals, inflammation persisted until a period of intensive, repeated intravitreal voriconazole injections administered during inpatient admission resulted in clinical regression.
findingsQuambalaria is an exceptionally rare ocular pathogen that can cause aggressive endophthalmitis.
publication datePublication date: 2026-09-21
limitationsTitle: Opportunistic Quambalaria fungal endophthalmitis in fumarate-treated multiple sclerosis complicated by multifocal postinfectious cerebral vasculopathy.
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