MRI Analysis in Relapsing-Remitting Multiple Sclerosis Patients and Healthy Controls
In a study comparing 20 RRMS patients to 10 healthy controls (HC), significant effects were observed in brain metrics R1 and R2, with RRMS showing lower values in 14 out of 16 regions of interest (ROIs). However, the group differences for age, sex, and some specific MRI measurements did not reach significance.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
These findings highlight the differences in brain tissue characteristics between RRMS patients and healthy individuals, which could be important for understanding disease progression and developing diagnostic tools.
What this does not prove
The study showed non-significant results for age and sex, which may limit the generalizability of the findings. Additionally, certain anisotropy comparisons did not yield significant results, leaving some unanswered questions.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceMulti-Parametric Phase-Cycled Balanced Steady-State Free Precession Brain Tissue Characterization in Relapsing-Remitting Multiple Sclerosis. ↗DOI: 10.1002/jmri.70594
Supporting passages (8)
study designSTATISTICAL TESTS: Linear mixed-effects models tested group, ROI, and group-by-ROI effects for each metric.
subjectsPOPULATION: Twenty RRMS patients (34.5 ± 5.9 years, female 15/20) and 10 HC subjects (33.4 ± 6.9 years, female 5/10).
study phaseEVIDENCE LEVEL: 2.
speciesPOPULATION: Twenty RRMS patients (34.5 ± 5.9 years, female 15/20) and 10 HC subjects (33.4 ± 6.9 years, female 5/10).
findingsRESULTS: Significant group, ROI, and group-by-ROI effects were found for R1 (β = -0.16) and R2 (β = -2.84). The ROI effect was significant for AI while the group (p = 0.450) and group-by-ROI (p = 0.747) effects were non-significant. Age and sex covariates did not reach significance (Age: p = [0.563, 0.705, 0.591], Gender: p = [0.839, 0.822, 0.179], for [R1, R2, AI]). Fourteen of 16 ROIs showed significantly lower R1 and R2 (d = -4.25 to -0.85) in RRMS than HC. All ROIs remained non-significant for AI. R2 (pcorr ≥ 0.055) and AI (pcorr ≥ 0.108) anisotropy comparison between RRMS and HC groups did not reach significance.
publication datePublication date: 2026-10-21
limitationsTitle: Multi-Parametric Phase-Cycled Balanced Steady-State Free Precession Brain Tissue Characterization in Relapsing-Remitting Multiple Sclerosis.
peer reviewedPublication types: Journal Article
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