Sexual Counseling Effects in Women with Multiple Sclerosis
The study assessed the impact of sexual counseling using the PLISSIT Model on sexual function and quality of life in women with MS over 12 months. Significant improvements were noted for primary sexual dysfunction (p = 0.029) and secondary sexual dysfunction (p < 0.001), along with increased intercourse frequency (p < 0.001) after 6 and 12 months. However, Bonferroni comparisons within the counseling group were nonsignificant (all p > 0.05).
- Tags
- #Other
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Not graded
- Outcome
- Not reported
Why it matters
This research highlights the potential benefits of targeted sexual counseling for women with MS, addressing an important yet often overlooked aspect of their quality of life. Improved sexual function and frequency could significantly enhance overall well-being and intimacy in this population.
What this does not prove
Despite observed improvements, the nonsignificant Bonferroni comparisons suggest that the results should be interpreted cautiously and indicate that further investigation is needed to confirm these findings.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-20
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Women aged 18-45 years with Multiple Sclerosis
- Size of effect
- p < 0.001 for intercourse frequency improvement
- Secondary endpoints
- Intercourse frequency
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceThe Effect of Sexual Counseling with the PLISSIT Model on Sexual Function and Sexual Quality of Life in Women with Multiple Sclerosis: A Randomized Controlled Trial. ↗DOI: 10.1080/0092623x.2026.2751561
Supporting passages (12)
speciesWomen with Multiple Sclerosis
publication date2026-10-20
interventionTitle: The Effect of Sexual Counseling with the PLISSIT Model on Sexual Function and Sexual Quality of Life in Women with Multiple Sclerosis: A Randomized Controlled Trial.
primary endpointOutcomes were assessed at baseline and 3, 6, and 12 months using the Multiple Sclerosis Intimacy and Sexuality Questionnaire-15 (MSISQ-15), Sexual Quality of Life Questionnaire-Female (SQOL-F), and self-reported weekly intercourse frequency.
follow up3, 6, and 12 months
findingsSignificant group × time interactions occurred for MSISQ-15 total (p = 0.006), primary sexual dysfunction (p = 0.029), and secondary sexual dysfunction (p < 0.001), although Bonferroni comparisons were nonsignificant in the counseling group (all p > 0.05).
limitationsBonferroni comparisons were nonsignificant in the counseling group (all p > 0.05)
populationTitle: The Effect of Sexual Counseling with the PLISSIT Model on Sexual Function and Sexual Quality of Life in Women with Multiple Sclerosis: A Randomized Controlled Trial.
secondary endpointsIntercourse frequency
effect sizeIntercourse frequency was higher with counseling at 6 (p < 0.001) and 12 months (p = 0.004).
peer reviewedPublication types: Journal Article
subjectsTitle: The Effect of Sexual Counseling with the PLISSIT Model on Sexual Function and Sexual Quality of Life in Women with Multiple Sclerosis: A Randomized Controlled Trial.
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