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Research summary · AI summary · not yet reviewedHuman studyObservationalPublished in a peer-reviewed journal
Human Study on Biomarkers in Relapsing-Remitting Multiple Sclerosis
In a study of 31 patients with relapsing-remitting MS compared to 30 healthy controls, MS patients had lower DTI-ALPS values and higher periventricular QSM values. There was a strong negative correlation between these biomarkers (r = -0.738), and both were linked to disability measured by EDSS.
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This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
These findings suggest potential biomarkers related to multiple sclerosis severity and may help in understanding disease mechanisms.
What this does not prove
The study's cross-sectional design prevents establishing causality between the observed associations.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 31 · 31 patients with RRMS
- Randomised
- No
- Controlled
- Yes
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-26
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- Not reported
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidencePerivascular Diffusivity and Periventricular Susceptibility Changes in Relapsing-Remitting Multiple Sclerosis: A Combined DTI-ALPS and QSM Study. ↗DOI: 10.1002/jmri.70604
Supporting passages (13)
study phaseSTAGE OF TECHNICAL EFFICACY: 2.
study designSTUDY TYPE: Retrospective case-control study.
subjectsThirty one patients with RRMS (mean age, 34.6 ± 8.4 years) and 30 age- and sex-matched healthy controls (mean age, 34.2 ± 8.1 years).
speciesThirty one patients with RRMS (mean age, 34.6 ± 8.4 years) and 30 age- and sex-matched healthy controls (mean age, 34.2 ± 8.1 years).
sample sizeThirty one patients with RRMS (mean age, 34.6 ± 8.4 years) and 30 age- and sex-matched healthy controls (mean age, 34.2 ± 8.1 years).
sample size basisThirty one patients with RRMS (mean age, 34.6 ± 8.4 years) and 30 age- and sex-matched healthy controls (mean age, 34.2 ± 8.1 years).
randomizedSTUDY TYPE: Retrospective case-control study.
controlledSTUDY TYPE: Retrospective case-control study.
peer reviewedJournal: Journal of magnetic resonance imaging : JMRI
findingsRESULTS: DTI-ALPS was lower in MS patients than controls (1.27 ± 0.22 vs. 1.45 ± 0.22; d = 0.828), whereas periventricular QSM was higher (-15.35 ± 4.92 vs. -21.70 ± 6.40 ppb; d = 1.116). A strong negative correlation between the two biomarkers was observed across all subjects (r = -0.738). Both measures correlated with EDSS (DTI-ALPS r = -0.509; QSM r = 0.501) and differed between EDSS subgroups (EDSS > 2.0 vs. ≤ 2.0: DTI-ALPS 1.160 vs. 1.364; QSM -12.33 vs. -17.83 ppb).
publication datePublication date: 2026-10-26
limitationsTitle: Perivascular Diffusivity and Periventricular Susceptibility Changes in Relapsing-Remitting Multiple Sclerosis: A Combined DTI-ALPS and QSM Study.
peer reviewedPublication types: Journal Article
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