Mortality Rate in EAE Mice Exposed to PFOS and βCD Treatment
In a study on EAE mice, exposure to PFOS resulted in a significant increase in mortality (60%) when fed standard chow. However, mice treated with βCD showed a reduced mortality rate of 12%. This suggests that βCD may counteract some of the toxic effects of PFOS in this model.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
The findings suggest a potential protective effect of βCD against PFOS toxicity in mice, which could lead to further investigation of βCD's role in other contexts, although results cannot be directly applied to humans.
What this does not prove
Results are based on a mouse model, lacking peer review, and do not confirm βCD as a treatment for MS. Regulatory approval for such use is not established.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Not reported
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-02-10
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceOrally-administered beta-cyclodextrin as a novel countermeasure for perfluorooctane sulfonic acid toxicity in mice. ↗DOI: 10.1080/24734306.2026.2728767
Supporting passages (6)
publication date2026-02-10
primary endpointIn contrast, in PFOS-exposed EAE mice provided βCD chow, mortality was reduced to 12% (1/8).
follow upBy 10 days post immunization, PFOS-exposed EAE kept on standard chow began to die, reaching nearly 60% mortality (5/8) at day 17.
findingsRESULTS: Control EAE mice exhibited typical disease progression, irrespective of being on standard or βCD chow.
findingsIn contrast, in PFOS-exposed EAE mice provided βCD chow, mortality was reduced to 12% (1/8).
limitationsTitle: Orally-administered beta-cyclodextrin as a novel countermeasure for perfluorooctane sulfonic acid toxicity in mice.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.