Cognitive and Motor Performance in Patients with Active Versus Inactive Secondary Progressive Multiple Sclerosis
In a study with 38 patients with secondary progressive multiple sclerosis (pwSPMS), active patients had lower neuropsychological test variable scores compared to inactive ones, indicating worse cognitive and motor performance. However, no significant difference was noted in TAI between the two groups.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
These findings suggest that cognitive and motor decline may be more pronounced in active SPMS, which could inform treatment strategies and monitoring approaches for this patient population.
What this does not prove
The study's observational nature limits causal inferences and it does not account for potential confounding factors in cognitive and motor assessments.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 38 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-01
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- 38 pwSPMS (15 active and 23 inactive)
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceThalamic atrophy in active and inactive secondary progressive multiple sclerosis patients: A comparative study. ↗DOI: 10.22088/cjim.17.3.595
Supporting passages (8)
study designIn this cross-sectional study, 38 pwSPMS (15 active and 23 inactive) were enrolled from February to November 2024.
subjectsThis study aimed to compare the TAI between active and inactive pwSPMS and to examine its relationship with key clinical, cognitive, and motor variables.
sample size38 pwSPMS (15 active and 23 inactive) were enrolled from February to November 2024.
populationMETHODS: In this cross-sectional study, 38 pwSPMS (15 active and 23 inactive) were enrolled from February to November 2024.
findingsRESULTS: Active SPMS patients had significantly lower NTV compared to inactive patients (Cohen's d = -1.58, p < 0.001).
limitationsNo significant difference in TAI was observed between groups.
publication datePublication date: 2026-09-01
peer reviewedPublication types: Journal Article
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