Cognitive Testing Decline in People with Multiple Sclerosis
In a study of 334 people with multiple sclerosis, 14.7% were found to have declined neurocognitive testing. Factors linked to this decision included progressive MS, anxiety disorders, and not reporting cognitive issues.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding who declines neurocognitive testing can help identify patients at risk for cognitive impairment. It also underscores the potential impact of psychological factors and disease progression on testing participation.
What this does not prove
The study does not confirm that the identified clinical characteristics cause people to decline cognitive testing, only that they are associated with the decision.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 334 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-17
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceWho declines neurocognitive testing? A cross-sectional study in people with multiple sclerosis. ↗DOI: 10.1177/13524585261491122
Supporting passages (7)
study designIn 334 people with multiple sclerosis, a backward stepwise regression analysis was conducted to identify clinical characteristics that predict who declines neurocognitive testing (p < 0.05), from demographics, disease-related variables, psychiatric diagnoses, and self-reported cognitive concerns.
subjectsIn 334 people with multiple sclerosis, a backward stepwise regression analysis was conducted to identify clinical characteristics that predict who declines neurocognitive testing (p < 0.05), from demographics, disease-related variables, psychiatric diagnoses, and self-reported cognitive concerns.
sample sizeIn 334 people with multiple sclerosis, a backward stepwise regression analysis was conducted to identify clinical characteristics that predict who declines neurocognitive testing (p < 0.05), from demographics, disease-related variables, psychiatric diagnoses, and self-reported cognitive concerns.
publication date2026-10-17
primary endpointIndependent correlates of declining neurocognitive testing included progressive MS (odds ratio = 2.1, 95% confidence interval = [1.0, 4.4], p = 0.046), anxiety-related disorders (odds ratio = 2.5, 95% confidence interval = [1.3, 4.9], p = 0.007), and the absence of self-reported cognitive concerns (odds ratio = 0.3, 95% confidence interval = [0.2, 0.7], p = 0.004).
findingsIndependent correlates of declining neurocognitive testing included progressive MS (odds ratio = 2.1, 95% confidence interval = [1.0, 4.4], p = 0.046), anxiety-related disorders (odds ratio = 2.5, 95% confidence interval = [1.3, 4.9], p = 0.007), and the absence of self-reported cognitive concerns (odds ratio = 0.3, 95% confidence interval = [0.2, 0.7], p = 0.004).
limitationsTitle: Who declines neurocognitive testing? A cross-sectional study in people with multiple sclerosis.
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