Bilateral Internuclear Ophthalmoplegia After Minor Head Trauma: A Case Report
A 61-year-old woman experienced bilateral internuclear ophthalmoplegia (INO) following a minor motorbike accident. Initial CT scans were normal, but an MRI two days later showed a brain injury characterized by paramedian pontomesencephalic hyperintensity, indicating trauma-related axonal damage.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Positive
Why it matters
This case highlights the possibility of developing bilateral INO from minor head injuries, which is not commonly recognized. Understanding this association could impact future assessments of head trauma consequences.
What this does not prove
Case reports lack generalizability and do not prove causation. Thus, more research is needed to establish the broader implications of such findings.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Case report
- Participants / samples
- 1 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-29
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- 61-year-old Asian woman with bilateral INO after minor head injury
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidenceBilateral Internuclear Ophthalmoplegia Caused by Minor Head Injury: A Case Report. ↗DOI: 10.4103/ant.ant-d-25-00043
Supporting passages (12)
study designPublication types: Journal Article; Case Reports
subjectsMeSH terms: Humans; Female; Middle Aged
sample sizeBilateral internuclear ophthalmoplegia (INO) is rare, with vascular disease and multiple sclerosis being the most common causes. We report an unusual case of isolated bilateral INO following minor brain injury.
peer reviewedJournal: Acta neurologica Taiwanica
findingsInitial brain computed tomography was unremarkable, but brain magnetic resonance imaging (MRI) 2 days later revealed a subtle paramedian pontomesencephalic hyperintensity on T2-weighted imaging, which became more pronounced with contrast enhancement, suggesting the axonal injury secondary to trauma.
limitationsAlthough rare, isolated bilateral INO should be considered posthead trauma.
populationA 61-year-old Asian woman developed binocular diplopia after a minor motorbike accident.
outcomeInitial brain computed tomography was unremarkable, but brain magnetic resonance imaging (MRI) 2 days later revealed a subtle paramedian pontomesencephalic hyperintensity on T2-weighted imaging, which became more pronounced with contrast enhancement, suggesting the axonal injury secondary to trauma.
publication datePublication date: 2026-10-29
peer reviewedPublication types: Journal Article; Case Reports
subjectsMeSH terms: Humans; Female; Middle Aged; Magnetic Resonance Imaging; Ocular Motility Disorders; Craniocerebral Trauma
subjectsPublication types: Journal Article; Case Reports
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