Physical and Psychological Impact in Adults with Relapsing-Remitting MS
In a study of 100 adults with relapsing-remitting MS, researchers found that female sex, Expanded Disability Status Scale (EDSS) scores, and certain psychological scales were significantly associated with both physical and psychological impacts of the disease. However, disease duration did not predict these impacts. Overall, physical and psychological scores were 36.7 and 45.3 respectively, indicating notable burdens in this population.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Not established from this source
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
These findings highlight significant associations between gender and psychological factors related to physical health in MS, suggesting a need to consider gender differences in disease impact assessment.
What this does not prove
The study does not prove causation, as disease duration was not a predictor of physical or psychological impact, and the findings are not generalizable beyond the sample studied.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 100 · basis not reported
- Randomised
- No
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- RRMS
- Publication date
- 2026-10-23
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- adults aged 18 to 55 years with relapsing-remitting MS (RRMS)
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidencePhysical and psychological burden in RRMS: depression and fatigue beyond disease duration. ↗DOI: 10.1055/s-0046-1829129
Supporting passages (11)
subjectsHuman
sample size100
randomizedNo
relevant ms typesRRMS
publication date2026-10-23
populationadults aged 18 to 55 years with relapsing-remitting MS (RRMS)
findingsRESULTS: A total of 57 participants (57%) were female patients. The mean age was 38.5 ± 8.0 years, and the mean disease duration, 9.8 ± 6.8 years. The mean MSIS-29 physical and psychological scores were 36.7 ± 15.7 and 45.3 ± 20.4 respectively. No significant differences were found between patients with disease duration ≤ 10 and > 10 years in terms of the physical (p = 0.263) or psychological (p = 0.551) subscales. Physical impact was significantly associated with the female sex (p = 0.021) and the scpres on the EDSS (p = 0.030), BDI (p < 0.001), and FSS (p < 0.001). Psychological impact showed significant associations with the female sex (p = 0.005), ARR (p = 0.020), and the scores on the BDI (p < 0.001), and FSS (p < 0.001). On multivariate regression, the scores on the EDSS, BDI, and 25-FWT were independent predictors of physical impact, while the female sex and the scores on the EDSS and BDI were independent predictors of psychological impact.
limitationsTitle: Physical and psychological burden in RRMS: depression and fatigue beyond disease duration.
peer reviewedPublication types: Journal Article
subjectsMeSH terms: Humans; Female; Adult; Fatigue; Male; Middle Aged; Quality of Life; Time Factors; Severity of Illness Index; Depression; Multiple Sclerosis, Relapsing-Remitting; Young Adult; Disability Evaluation; Adolescent; Psychiatric Status Rating Scales; Symptom Burden; Cross-Sectional Studies; Socioeconomic Factors
study designMeSH terms: Humans; Female; Adult; Fatigue; Male; Middle Aged; Quality of Life; Time Factors; Severity of Illness Index; Depression; Multiple Sclerosis, Relapsing-Remitting; Young Adult; Disability Evaluation; Adolescent; Psychiatric Status Rating Scales; Symptom Burden; Cross-Sectional Studies; Socioeconomic Factors
AI assessment, not yet reviewed by a person · version 2 · Community votes are separate from evidence review.