AI CuratorAI-generated
Research summary · AI summary · not yet reviewedHuman studyInterventionalTrial registry
Psychological Interventions in RRMS Patients
A study with 148 participants diagnosed with relapsing-remitting multiple sclerosis (RRMS) aimed to evaluate whether Group-Based Cognitive-Behavioral Therapy (CBT) and Psychophysiological Regulation Therapy (PRT) could improve emotional well-being and cognitive functioning. Participants were randomly assigned to one of three conditions: CBT, PRT, or Standard Care (waiting-list control).
- Tags
- #MSResearch
- Most relevant to
- —
- Source
- Read original source
This plain-English summary was written by AI from a published abstract and may contain errors. It is not medical advice. Read the original study and talk to your MS team before making decisions about treatment.
Why it matters
Understanding the effectiveness of psychological interventions may offer new avenues for improving the mental health and cognitive abilities of individuals with RRMS.
What this does not prove
No results are available, making it impossible to determine the efficacy of the interventions. Details about planned endpoints were not disclosed.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Interventional
- Participants / samples
- Not reported
- Randomised
- Yes
- Controlled
- Yes
- Primary endpoint met
- Not reported
- Relevant MS type
- RRMS
- Publication date
- Not reported
- Evidence reviewed
- Trial registry record
- Regulatory approval
- No
- Research areas
- Not classified
Original sources
Supporting passages (8)
study designThis study employed a three-arm randomized controlled parallel design.
subjectsThe main objective was to evaluate whether Group-Based Cognitive-Behavioral Therapy (CBT) and Psychophysiological Regulation Therapy (PRT) improved emotional well-being and objective cognitive functioning compared with Standard Care (SC).\n\nA total of 153 individuals with RRMS were assessed for eligibility, of whom 148 were randomized to one of three study conditions: Group-Based CBT, PRT, or SC (waiting-list control).
randomizedFive individuals were excluded (three declined to participate and two did not meet the inclusion criteria), resulting in a final randomized sample of 148 participants.\n\nParticipants were randomly allocated to one of three parallel study conditions: Group-Based Cognitive-Behavioral Therapy (CBT), Psychophysiological Regulation Therapy (PRT; active comparator), or Standard Care (SC; waiting-list control).
controlledParticipants were allocated using a simple computer-generated randomization sequence with a 1:1:1 allocation ratio.\n\nBoth active interventions were delivered in small groups over 12 weekly sessions.
regulatory approvalFive individuals were excluded (three declined to participate and two did not meet the inclusion criteria), resulting in a final randomized sample of 148 participants.\n\nParticipants were randomly allocated to one of three parallel study conditions: Group-Based Cognitive-Behavioral Therapy (CBT), Psychophysiological Regulation Therapy (PRT; active comparator), or Standard Care (SC; waiting-list control).
relevant ms types"eligibilityCriteria": "Inclusion Criteria:\n\n* Diagnosis of relapsing-remitting multiple sclerosis according to standard clinical criteria.\n* Expanded Disability Status Scale (EDSS) score between 0 and 3.5.\n* Mild to moderate cognitive impairment defined as: up to two BRB-N subtests with scores \\< -2 SD.\n* Presence of anxiety or depressive symptoms defined as:\n* HADS: score \\> 8 on one or both subscales, and/or\n* BDI-II: score \\> 8.\n* Stable disease-modifying treatment for ≥ 3 months.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Progressive forms of multiple sclerosis (SPMS or PPMS).\n* Severe cognitive impairment preventing participation in psychological sessions.\n* Active psychiatric or neurological disorders unrelated to MS.\n* Participation in another psychological or pharmacological intervention study.\n* Recent initiation or modification of disease-modifying treatment (\\< 3 months).\n* Substance abuse or dependence within the past year.\n* Inability to provide informed consent.",
findings"briefSummary": "This study evaluated the efficacy of two structured psychological interventions in individuals with relapsing-remitting multiple sclerosis (RRMS).
limitationsTrial registry record. Publication date: unknown. No results are posted. Planned enrolment and endpoints are not findings.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.