Human Study of MS Participants Using T25-FW and SF-36
In a study of 759 people with multiple sclerosis (MS) from the TEAMS trial, performance on the T25-FW test showed a strong connection with SF-36 physical functioning scores, even after demographic adjustments. This suggests that faster T25-FW times are associated with better physical health as reported by participants.
- Tags
- #MSResearch
- Most relevant to
- —
Why it matters
This finding is important because it highlights a measurable way to assess physical functioning in people with MS, potentially aiding in evaluating their health outcomes.
What this does not prove
However, the study notes that there are few studies that have rigorously examined the validity of T25-FW against patient-reported outcomes. Thus, further strong evidence is needed to confirm these associations.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- 759 · participants with MS enrolled in Tele-Exercise and Multiple Sclerosis (TEAMS) trial
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-09-21
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceConstruct validity of the timed 25-foot walk and robustness of clinical benchmarks in multiple sclerosis: exploratory analyses of TEAMS study. ↗DOI: 10.1016/j.ensci.2026.100623
Supporting passages (9)
study phaseClinical trial registration: ClinicalTrials.gov Identifier: NCT03117881.
study designTo examine the construct validity of T25-FW using patient-reported health outcomes and to evaluate robustness of previously proposed clinical benchmarks.
subjectsBaseline data from 759 participants with MS enrolled in Tele-Exercise and Multiple Sclerosis (TEAMS) trial were analyzed.
sample sizeBaseline data from 759 participants with MS enrolled in Tele-Exercise and Multiple Sclerosis (TEAMS) trial were analyzed.
sample size basisBaseline data from 759 participants with MS enrolled in Tele-Exercise and Multiple Sclerosis (TEAMS) trial were analyzed.
primary endpoint metRESULTS: T25-FW performance showed a strong association with SF-36 physical functioning (ρ = -0.71), which remained significant after adjustment for demographic factors (ρ = -0.39).
findingsRESULTS: T25-FW performance showed a strong association with SF-36 physical functioning (ρ = -0.71), which remained significant after adjustment for demographic factors (ρ = -0.39).
limitationsFewer studies have examined its construct validity relative to patient-reported outcomes or assessed robustness of previously proposed benchmarks in large cohorts.
publication datePublication date: 2026-09-21
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