Human Research on the Gut-Brain Axis and Neurodegenerative Diseases
This systematic review discusses the role of the gut-brain axis (GBA) in the development of neurodegenerative diseases, including multiple sclerosis (MS). It highlights how changes in gut microbiota can impact the central nervous system, and explores potential therapies like probiotics and fecal microbiota transplantation (FMT).
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding the connections between gut microbiota and neurodegenerative diseases could open new avenues for prevention and treatment strategies.
What this does not prove
The review points out significant knowledge gaps about the causality of gut microbiota changes, molecular mechanisms, and the clinical effectiveness of GBA-targeted therapies.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-10
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Neuroinflammation, Other
Original sources
- Primary evidenceThe Gut-Brain Axis and Neurodegenerative Diseases: From Mechanistic Pathways to Therapeutic Interventions. ↗DOI: 10.1007/s12602-026-11246-w
Supporting passages (7)
study designThis review systematically introduces the pathogenic characteristics of representative NDDs such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), as well as the association mechanisms between these diseases and GBA.
subjectsNeurodegenerative diseases have complex pathogenesis and currently lack fundamental treatment methods.
research categoriesThis article aims to review the mechanisms of the interaction between the gut microbiota and the brain in neurodegenerative diseases, and based on the existing experimental evidence, provide theoretical basis and future development directions for future prevention and treatment strategies targeting GBA.
publication date2026-10-10
interventionThese changes influence the CNS through multiple pathways, including neuroendocrine, vagus nerve, and immune regulation, ultimately contributing to the onset and progression of the diseases.
findingsNevertheless, major knowledge gaps remain, particularly regarding causality between gut microbiota changes and NDDs, the underlying molecular mechanisms, and the clinical efficacy of GBA-targeted therapies.
limitationsThis article aims to review the mechanisms of the interaction between the gut microbiota and the brain in neurodegenerative diseases, and based on the existing experimental evidence, provide theoretical basis and future development directions for future prevention and treatment strategies targeting GBA.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.