Aerobic Exercise in Multiple Sclerosis: Feasibility Study with Animal/Cell Subjects
In a feasibility clinical trial with 32 participants, those assigned to an aerobic cycling intervention (MS:Cycle) showed a median decrease in Somatosensory Evoked Potentials z-score by 0.61 after 24 weeks, while control participants showed an increase of 0.24. Additionally, the MS:Cycle group improved their 6-Minute Timed Walk by an average of 52 meters compared to controls at the same time point.
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Why it matters
These findings suggest that aerobic exercise may have positive effects on certain measures related to multiple sclerosis, including potentially beneficial changes in sensory processing and mobility.
What this does not prove
This report is based on trial protocol and does not provide final results or conclusive evidence of efficacy. External medications and interventions were not accounted for, which could affect outcomes.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Interventional
- Participants / samples
- 32 · basis not reported
- Randomised
- Yes
- Controlled
- Yes
- Primary endpoint met
- No
- Relevant MS type
- Not reported
- Publication date
- Not reported
- Evidence reviewed
- Trial registry record
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Trial registrationAerobic Exercise for Remyelination in Multiple Sclerosis ↗
Supporting passages (8)
sample sizeHowever, one participant could not adequately complete the necessary VO2-maz testing and was excluded, so 32 participants were randomized.",
subjectsThis is a clinical trial to determine the feasibility of a stationary aerobic cycling intervention and explore if aerobic exercise independently promotes remyelination in people with multiple sclerosis (MS).
randomizedTwenty-two participants in the clinical trial arm will be randomized to MS:Cycle: an aerobic exercise intervention on a stationary ergometer.
controlledTwenty-two participants in the clinical trial arm will be randomized to MS: Take Control (MSTC): a monthly, hour-long MS education control group led by a trained facilitator.
primary endpoint met"description": "Somatosensory evoked potentials (SSEPs) are a measure of functional myelination of the somatosensory tracts (i.e., the time it takes for a sensory signal to travel from the limb to the cortex).
study designAdditionally, as remyelination occurs over 12 to 24 weeks, it is imperative to establish the feasibility of similar duration of aerobic exercise interventions, and explore if exercise independently influences established remyelination outcomes before integration into multimodal strategies.\n\nThis is a randomized, single-blind, parallel clinical trial of a 24-week aerobic stationary cycling intervention to determine feasibility and explore if aerobic exercise independently promotes remyelination in pwMS."
findingsHowever, one participant could not adequately complete the necessary VO2-maz testing and was excluded, so 32 participants were randomized.",
limitationsTrial registry record. Publication date: unknown. Sponsor-submitted results are available; this does not establish peer review.
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