Observational Study on Rare Childhood Neurological Diseases
From 1990 to 2021, the prevalence of rare childhood neurological diseases increased globally, with projections indicating 110.2 thousand affected children by 2050, an 11.83% rise from 2021. Higher rates were observed among boys and in countries with low-middle sociodemographic indices.
- Tags
- #Other
- Most relevant to
- —
- Human efficacy
- Not yet assessed
- Mechanism
- Not yet assessed
- Evidence strength
- Not yet assessed
- Outcome
- Not yet assessed
Why it matters
Understanding these trends emphasizes the growing burden of these diseases and the need for targeted prevention efforts, particularly in vulnerable populations.
What this does not prove
The study does not analyze therapeutic efficacy for multiple sclerosis or provide insights from clinical trials, focusing exclusively on epidemiological data.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Observational
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-10-05
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Other
Original sources
- Primary evidenceGlobal epidemiological and genetic burden of rare neurological diseases in children. ↗DOI: 10.1016/j.isci.2026.117791
Supporting passages (8)
study phaseFour neurological conditions were classified as rare childhood neurological diseases: motor neuron disease, multiple sclerosis, neuroblastoma and other peripheral nervous cell tumors, and other neurological disorders.
study designWe assessed the global burden of rare childhood neurological diseases from 1990 to 2021 and projected trends to 2050 using Global Burden of Disease data, alongside an analysis of the genetic burden from ClinVar.
subjectshigher burdens among boys and in low-middle sociodemographic index countries.
sample size basisFrom 1990 to 2021, the global age-standardized prevalence and disability-adjusted life-year rates of rare childhood neurological diseases increased, with higher burdens among boys and in low-middle sociodemographic index countries.
research categoriesThe increasing and disparate burden of rare childhood neurological diseases highlights the need for targeted prevention.
publication date2026-10-05
findingsFrom 1990 to 2021, the global age-standardized prevalence and disability-adjusted life-year rates of rare childhood neurological diseases increased, with higher burdens among boys and in low-middle sociodemographic index countries.
limitationsTitle: Global epidemiological and genetic burden of rare neurological diseases in children.
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.