Clinical Case Report of a 65-Year-Old Woman with Primary Progressive Multiple Sclerosis (PPMS)
A 65-year-old woman with established PPMS experienced acute bilateral lower-limb weakness along with fever and sore throat. After treatment, she showed significant clinical improvement, returning to baseline mobility and functional status. At a two-month follow-up, she remained clinically stable with no new neurological deficits.
- Tags
- #MSResearch
- Most relevant to
- —
- Human efficacy
- Demonstrated in people
- Mechanism
- Not reported
- Evidence strength
- Limited
- Outcome
- Not reported
Why it matters
This case underscores the need to differentiate between pseudo-relapses and true relapses in PPMS, which can affect treatment approaches and patient management.
What this does not prove
No contemporaneous MRI was performed; thus, diagnosis and treatment were based solely on clinical assessments, limiting the scope of the findings.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Case report
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- PPMS
- Publication date
- 2026-09-29
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
- Biological target
- Not reported
- Pathway
- Not reported
- Population
- 65-year-old woman with established PPMS
- Size of effect
- Not reported
- Secondary endpoints
- Not reported
- MRI endpoints
- Not reported
- Biomarkers
- Not reported
- Safety
- Not reported
Original sources
- Primary evidencePseudo-Exacerbation in Primary Progressive Multiple Sclerosis: A Case Report. ↗DOI: 10.7759/cureus.117167
Supporting passages (10)
study designPublication types: Case Reports; Journal Article
relevant ms typesPrimary progressive multiple sclerosis (PPMS) is characterised by gradual neurological deterioration from disease onset without distinct relapses.
populationthe case of a 65-year-old woman with established PPMS who presented with fever, sore throat, and acute bilateral lower-limb weakness.
findingsSignificant clinical improvement was observed, with return to baseline mobility and functional status.
findingsAt the two-month follow-up, she remained clinically stable with no new neurological deficits.
limitationsAs no contemporaneous MRI was performed, the diagnosis and treatment were based on clinical grounds.
human efficacyThis case highlights the importance of distinguishing pseudo-relapse from true relapse in patients with PPMS presenting with acute neurological deterioration.
publication datePublication date: 2026-09-29
peer reviewedPublication types: Case Reports; Journal Article
subjectsPublication types: Case Reports; Journal Article
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.