Ferroptosis in Neurodegenerative Diseases (Animal/Cell Studies)
This systematic review discusses how ferroptosis is connected to neurodegenerative diseases, including Multiple Sclerosis, highlighting the role of iron metabolism disruptions and oxidative stress. It suggests that therapies like radical-trapping antioxidants and iron chelators show potential in targeting ferroptosis.
- Tags
- #Neuroprotection
- Most relevant to
- —
Why it matters
Understanding ferroptosis could lead to new therapeutic strategies for neurodegenerative diseases, potentially improving treatment options.
What this does not prove
The review does not provide direct experimental results or clinical trial outcomes, meaning it does not confirm any therapies' efficacy in humans.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-17
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Neuroprotection
Original sources
- Primary evidenceFerroptosis in Neurodegenerative Diseases: Iron Dysregulation, GPX4/FSP1 Signaling, and Emerging Neuroprotective Strategies. ↗DOI: 10.2174/0115672026502165260904054005
Supporting passages (7)
study phaseMETHODS: This review examines the molecular underpinnings of ferroptosis, focusing on dysregulation in iron homeostasis, increased vulnerability of polyunsaturated fatty acids in neuronal membranes, and impairment of antioxidant defence systems, particularly the Glutathione-GPX4 and FSP1-CoQ10-NADPH pathways.
study designMETHODS: This review examines the molecular underpinnings of ferroptosis, focusing on dysregulation in iron homeostasis, increased vulnerability of polyunsaturated fatty acids in neuronal membranes, and impairment of antioxidant defence systems, particularly the Glutathione-GPX4 and FSP1-CoQ10-NADPH pathways.
research categoriesDISCUSSION: Emerging therapeutic strategies, including radical-trapping antioxidants, iron chelators, and nanotechnology-based delivery systems, show potential in targeting ferroptosis.
interventionDISCUSSION: Emerging therapeutic strategies, including radical-trapping antioxidants, iron chelators, and nanotechnology-based delivery systems, show potential in targeting ferroptosis.
findingsFuture research integrating multiomics profiling, longitudinal clinical data, and advanced computational modelling is essential to validate the efficacy of ferroptosis-targeted interventions and facilitate their successful translation into precision neurotherapeutics.
publication datePublication date: 2026-09-17
limitationsTitle: Ferroptosis in Neurodegenerative Diseases: Iron Dysregulation, GPX4/FSP1 Signaling, and Emerging Neuroprotective Strategies.
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