Human Multimodal Lifestyle Program for MS Patients
A study involving 659 participants evaluated a 3-month lifestyle program combining a Mediterranean diet, physical activity, and stress management. The program led to significant reductions in MS-related daily functioning scores (MSIS-29) during the intervention, with modest ongoing improvements observed at 24 months.
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Why it matters
These results suggest lifestyle interventions could play a complementary role in managing MS, particularly regarding dietary changes and weight management.
What this does not prove
The study does not confirm long-term efficacy beyond 24 months and showed no significant changes in physical activity adherence.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Interventional
- Participants / samples
- 659 · basis not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Yes
- Relevant MS type
- Not reported
- Publication date
- 2026-09-24
- Evidence reviewed
- Abstract only
- Regulatory approval
- Yes
- Research areas
- Other
Original sources
- Primary evidenceSustained Benefits of a Multidomain Lifestyle Intervention in Multiple Sclerosis in the LIMS Study: A 24-Month Follow-Up. ↗DOI: 10.1212/wnl.0000000000218542
Supporting passages (12)
study designWe evaluated (1) whether effects on patient-reported outcomes were sustained up to 24 months and (2) long-term changes in lifestyle behaviors after completion of the lifestyle in MS program.
subjects659 participants were included (mean age 46 years, SD 11; 84% female).
sample sizeRESULTS: In total, 659 participants were included (mean age 46 years, SD 11; 84% female).
primary endpoint metDuring the intervention phase, MSIS-29 physical and psychological scores significantly decreased by approximately 0.8 and 1.1 points per month, respectively, followed by attenuation during long-term follow-up.
regulatory approvalTRIAL REGISTRATION INFORMATION: The study was registered at ClinicalTrials.gov (Identifier: NCT05402501; classic.clinicaltrials.gov/ct2/show/NCT05402501).
research categoriesThese findings support a complementary role for lifestyle interventions in long-term MS management.
interventionMETHODS: People with MS participated in a 3-month multimodal lifestyle program (i.e., Mediterranean-style diet, physical activity, and sleep and stress), followed by a 21-month maintenance phase.
primary endpointThe primary outcome was MS-related impact on daily functioning (MS Impact Scale-29 [MSIS-29]).
follow upPatient-reported outcomes were assessed 3 months before the intervention, at baseline, postintervention, and after 6, 12, 18, and 24 months.
findingsTrajectories were broadly similar across other patient-reported outcomes, with modest short-term improvements and subsequent stabilization.
limitationsMost pronounced effects were found for dietary adherence and body mass index, which improved substantially during the intervention and remained partially sustained during follow-up.
publication datePublication date: 2026-09-24
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