Human Study on Stereotactic Radiosurgery for Craniofacial Pain
This systematic review found that stereotactic radiosurgery (SRS) is an established treatment for trigeminal neuralgia associated with multiple sclerosis. However, its use for other conditions like glossopharyngeal neuralgia, trigeminal autonomic cephalalgias, and neuropathic facial pain is still investigational due to insufficient evidence.
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Why it matters
Understanding SRS's effectiveness for trigeminal neuralgia lays the groundwork for potential innovations in managing craniofacial pain disorders. However, the limited evidence for other pain types suggests caution.
What this does not prove
The review highlights the need for improved patient selection and more research to clearly define SRS's role in various craniofacial pain conditions, as current evidence is heterogeneous.
Next milestone
No next milestone was established from the available source.
Study facts
- Study design
- Systematic review
- Participants / samples
- Not reported
- Randomised
- Not reported
- Controlled
- Not reported
- Primary endpoint met
- Not reported
- Relevant MS type
- Not reported
- Publication date
- 2026-09-18
- Evidence reviewed
- Abstract only
- Regulatory approval
- Not reported
- Research areas
- Not classified
Original sources
- Primary evidenceStereotactic radiosurgery for craniofacial pain disorders: current clinical applications and future perspectives. ↗DOI: 10.1080/14737175.2026.2735964
Supporting passages (8)
study designThis review summarizes the current clinical indications, radiosurgical techniques, efficacy, safety, and limitations of SRS for medically refractory craniofacial pain disorders.
subjectsSRS is an established treatment for classical, idiopathic, and multiple sclerosis-related TN.
peer reviewedStereotactic radiosurgery for craniofacial pain disorders: current clinical applications and future perspectives.
findingsEXPERT OPINION: SRS is an established treatment for classical, idiopathic, and multiple sclerosis-related TN.
findingsAdvances in neuroimaging, radiosurgical technology, and treatment planning have expanded its application beyond trigeminal neuralgia (TN) to glossopharyngeal neuralgia (GN), trigeminal autonomic cephalalgias (TACs), and neuropathic facial pain (NFP).
limitationsFuture advances in neuroimaging, target localization, and understanding of craniofacial pain pathophysiology, together with well-designed studies, are expected to optimize patient selection and better define the role of SRS for those disorders.
limitationsIn contrast, its application to GN, tumor-related TN, TACs, and NFP remains investigational because of limited and heterogeneous evidence.
publication datePublication date: 2026-09-18
AI assessment, not yet reviewed by a person · version 1 · Community votes are separate from evidence review.